primaquine phosphate
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Names
[ CAS No. ]:
63-45-6
[ Name ]:
primaquine phosphate
[Synonym ]:
1,4-pentanediamine, N4-(6-methoxy-8-quinolinyl)-, phosphate (1:2)
N4-(6-methoxyquinolin-8-yl)pentane-1,4-diamine phosphate (1:2)
N-(6-Methoxy-8-quinolinyl)-1,4-pentanediamine phosphate (1:2)
EINECS 200-560-8
Primaquine phosphate
N-(6-Methoxyquinolin-8-yl)pentane-1,4-diamine phosphate (1:2)
Primaquine diphosphate
4-N-(6-methoxyquinolin-8-yl)pentane-1,4-diamine,phosphoric acid
Primaquine diphosphate salt
1,4-Pentanediamine, N-(6-methoxy-8-quinolinyl)-, phosphate (1:2)
primaquine bis(phosphate)
MFCD00013166
Primaquine (Diphosphate)
Chemical & Physical Properties
[ Boiling Point ]:
451.1ºC at 760 mmHg
[ Melting Point ]:
205-206 °C (dec.)(lit.)
[ Molecular Formula ]:
C15H27N3O9P2
[ Molecular Weight ]:
455.337
[ Flash Point ]:
226.6ºC
[ Exact Mass ]:
455.122253
[ PSA ]:
235.31000
[ LogP ]:
1.69880
[ Stability ]:
Stable. Incompatible with strong oxidizing agents.
[ Water Solubility ]:
moderately soluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VA9660000
- CAS REGISTRY NUMBER :
- 63-45-6
- LAST UPDATED :
- 199509
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C15-H21-N3-O.2H3-O4-P
- MOLECULAR WEIGHT :
- 455.39
- WISWESSER LINE NOTATION :
- T66 BNJ HO1 JMY1&3Z &..H3.P-O4 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 177 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 68 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 105 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Bird - domestic
- DOSE/DURATION :
- 19300 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 540 mg/kg
- SEX/DURATION :
- female 8-16 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 600 mg/kg
- SEX/DURATION :
- female 8-13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 480 mg/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - other effects
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Microorganism - not otherwise specified
- DOSE/DURATION :
- 5 mg/L
- REFERENCE :
- AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 1,259,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3750 No. of Facilities: 206 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 2809 (estimated) No. of Female Employees: 2111 (estimated)
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301
[ Precautionary Statements ]:
Missing Phrase - N15.00950417
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
[ Hazard Codes ]:
T:Toxic
[ Risk Phrases ]:
R25
[ Safety Phrases ]:
S45
[ RIDADR ]:
UN 2811 6.1/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
VA9660000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
2933499090
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933499090
[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Pharm. Dev. Technol. 18(5) , 1247-54, (2013)
A tablet formulation based on hydrophilic matrix with a controlled drug release was developed, and the effect of polymer concentrations on the release of primaquine diphosphate was evaluated. To achie...
J. Pharm. Biomed. Anal. 98 , 434-45, (2014)
Regular quality control and post-marketing surveillance of pharmaceuticals has been a critical challenge for countries of the developing world ever since. Counterfeit and substandard medicines are wid...
J. Pharm. Biomed. Anal. 95 , 200-6, (2014)
• Chloroquine, desethyl chloroquine and primaquine level were quantified simultaneously by HPLC-DAD. • The method validation parameters were adequate according international standards. • Sample prepar...