Asunaprevir

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Names

[ CAS No. ]:
630420-16-5

[ Name ]:
Asunaprevir

[Synonym ]:
Asunaprevir (JAN/USAN)
1,1-dimethylethyl [(1S)-1-{[(2S,4R)-4-(7-chloro-4methoxyisoquinolin-1-yloxy)-2-({(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}carbamoyl)pyrrolidin-1-yl]carbonyl}-2,2-dimethylpropyl]carbamate
tert-butyl (S)-1-((2S,4R)-4-(7-chloro-4-methoxyisoquinolin-1-yloxy)-2-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropylcarbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate
3-Methyl-N-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-valyl-(4R)-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-vinylcyclopropyl}-L-prolinamide
Cyclopropanecarboxamide, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-L-valyl-(4R)-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenyl-, (1R,2S)-
UNII-S9X0KRJ00S
CS-0674
L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-L-valyl-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-N-[(1R,2S)-1-[[(cyclopropylsulfonyl)amino]carbonyl]-2-ethenylcyclopropyl]-, (4R)-
Asunaprevir
N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C35H46ClN5O9S

[ Molecular Weight ]:
748.286

[ Exact Mass ]:
747.270447

[ PSA ]:
201.18000

[ LogP ]:
4.02

[ Index of Refraction ]:
1.616

[ Storage condition ]:
2-8°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (2S,4R)-4-(7-chloro-4-methoxyisoquinolin-1-yloxy)-N-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)pyrrolidine-2-carboxamide
  • Boc-Tle-OH
  • (2S,4R)-tert-butyl 4-((7-chloro-4-methoxyisoquinolin-1-yl)oxy)-2-(((1R,2S)-1-((cyclopropylsulfonyl)-carbamoyl)-2-vinylcyclopropyl)carbamoyl)pyrrolidine-1-carboxylate
  • 4-bromo-1,7-dichloroisoquinoline
  • 1,7-dichloro-4-methoxyisoquinoline
  • 3-(4-Chlorophenyl)acrylic acid
  • 7-Chloroisoquinolin-1-ol
  • 4-BROMO-7-CHLOROISOQUINOLIN-1(2H)-ONE

DownStream

Related Compounds

  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 5-bromo-1-oxetan-3-yl-1H-pyridin-2-one
  • ethyl 2-amino-3-(5-methyl-1H-pyrazol-1-yl)propanoate
  • [3-(1-cyclopentyl-1H-pyrazol-4-yl)propyl](methyl)amine
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • 4-(4-Fluoro-3-methylphenyl)pyrrolidin-2-one
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • 1-Fluoro-2-methoxy-4-(methylsulfanyl)benzene