2-Chloro-1-(4-hydroxyphenyl)ethanone

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Names

[ CAS No. ]:
6305-04-0

[ Name ]:
2-Chloro-1-(4-hydroxyphenyl)ethanone

[Synonym ]:
Ethanone, 2-chloro-1- (4-hydroxyphenyl)-
Ethanone, 2-chloro-1-(4-hydroxyphenyl)-
2-Chloro-1-(4-hydroxyphenyl)ethanone
EINECS 228-613-0

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
337.1±17.0 °C at 760 mmHg

[ Molecular Formula ]:
C8H7ClO2

[ Molecular Weight ]:
170.593

[ Flash Point ]:
157.7±20.9 °C

[ Exact Mass ]:
170.013458

[ PSA ]:
37.30000

[ LogP ]:
1.61

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.572

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KM5579000
CHEMICAL NAME :
Ethanone, 2-chloro-1-(4-hydroxyphenyl)-
CAS REGISTRY NUMBER :
6305-04-0
BEILSTEIN REFERENCE NO. :
2086326
LAST UPDATED :
199710
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C8-H7-Cl-O2
MOLECULAR WEIGHT :
170.60

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 12,581,1993
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 12,581,1993 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
230 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 12,581,1993
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 12,581,1993

Safety Information

[ HS Code ]:
2914700090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Chloroacetyl chloride
  • Phenol
  • 2-chloro-1-(4-chloroacetoxy-phenyl)-ethanone
  • 4-Hydroxyacetophenone
  • Anisole
  • Phenyl 2-chloroacetate
  • 2-Chloro-1-(4-methoxyphenyl)ethanone
  • Ortho-Hydroxyacetophenone
  • Aluminium chloride

DownStream

  • 4-(2-Methoxyethyl)phenol
  • [[p-(2-methoxyethyl)phenoxy]methyl]oxirane
  • 1-(4-HYDROXY-PHENYL)-2-[2-(4-HYDROXY-PHENYL)-2-OXO-ETHYLSULFANYL]-ETHANONE
  • 4-Hydroxyphenylacetic acid
  • 1,4-bis-(4-hydroxy-phenyl)-butane-1,4-dione
  • 4-Hydroxyacetophenone
  • S-(+)-2-octanol
  • (R)-(−)-2-Octanol
  • 3-(4-(2-Methoxyethyl)phenoxy)propane-1,2-diol

Customs

[ HS Code ]: 2914700090

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

Related Compounds

  • 2-Chloro-1-(4-fluoro-2-hydroxyphenyl)ethanone
  • [2-chloro-1-(4-hydroxyphenyl)-2-oxoethyl]ammonium chloride
  • 2-chloro-1-(2-chloro-4-hydroxyphenyl)ethanone
  • 2-chloro-1-(3,5-ditert-butyl-4-hydroxyphenyl)ethanone
  • 2-Chloro-1-[3-[[(1,1-dimethylethyl)imino]methyl]-4-hydroxyphenyl]ethanone
  • (R)-[2-chloro-1-(4-hydroxyphenyl)-2-oxoethyl]ammonium chloride