Terazosin hydrochloride
Suppliers
Names
[ CAS No. ]:
63074-08-8
[ Name ]:
Terazosin hydrochloride
[Synonym ]:
piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-
Terazosin
UNII:8L5014XET7
Vicard
Itrin
[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone,hydrochloride
Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)-
Urodie
[4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)methanone
6,7-bis(methyloxy)-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine
MFCD00467965
[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](tetrahydrofuran-2-yl)methanone
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
664.5±65.0 °C at 760 mmHg
[ Molecular Formula ]:
C19H26ClN5O4
[ Molecular Weight ]:
423.89
[ Flash Point ]:
355.7±34.3 °C
[ PSA ]:
103.04000
[ LogP ]:
-0.96
[ Appearance of Characters ]:
powder,white to off-white
[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C
[ Index of Refraction ]:
1.636
[ Storage condition ]:
Store at RT
[ Water Solubility ]:
H2O: 25 mg/mL
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TK8045000
- CHEMICAL NAME :
- Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahyd ro-2-furanyl)carbonyl )-, monohydrochloride
- CAS REGISTRY NUMBER :
- 63074-08-8
- LAST UPDATED :
- 199503
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C19-H25-N5-O4.Cl-H
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 277 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 7,435,1984 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4650 mg/kg/31D-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ptosis Nutritional and Gross Metabolic - body temperature decrease Related to Chronic Data - death
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 7,435,1984
Safety Information
[ Hazard Codes ]:
Xn,Xi
[ Risk Phrases ]:
22-36/37/38
[ Safety Phrases ]:
26-36
[ WGK Germany ]:
3
[ RTECS ]:
TK8044925