4-(4-methylpiperazin-1-yl)-8-(trifluoromethyl)-10H-thieno[3,4-b][1,5]benzodiazepine

Names

[ CAS No. ]:
63127-20-8

[ Name ]:
4-(4-methylpiperazin-1-yl)-8-(trifluoromethyl)-10H-thieno[3,4-b][1,5]benzodiazepine

[Synonym ]:
10-(4-Methyl-1-piperazinyl)-6-trifluoromethyl-4H-thieno(3,4-b)(1,5)benzodiazepine
4H-Thieno(3,4-b)(1,5)benzodiazepine,10-(4-methyl-1-piperazinyl)-6-trifluoromethyl

Chemical & Physical Properties

[ Density]:
1.46g/cm3

[ Boiling Point ]:
464.2ºC at 760 mmHg

[ Molecular Formula ]:
C17H17F3N4S

[ Molecular Weight ]:
366.40400

[ Flash Point ]:
234.5ºC

[ Exact Mass ]:
366.11300

[ PSA ]:
59.11000

[ LogP ]:
3.59900

[ Index of Refraction ]:
1.658

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XJ9008200
CHEMICAL NAME :
4H-Thieno(3,4-b)(1,5)benzodiazepine, 10-(4-methyl-1-piperazinyl)-6-trifluoromethyl-
CAS REGISTRY NUMBER :
63127-20-8
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C17-H17-F3-N4-S
MOLECULAR WEIGHT :
366.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 23,884,1980

Related Compounds

  • N-Butyl-2-chloro-N-methyl-4-pyrimidinamine
  • 2-[5-(3-chloro-4-methoxyphenyl)-4,6-dioxo-4,5,6,6a-tetrahydropyrrolo[3,4-d][1,2,3]triazol-1(3aH)-yl]-N-[3-(methylthio)phenyl]acetamide
  • 2-fluoro-N-[2-(4-fluorophenyl)-2-(4-methylpiperazin-1-yl)ethyl]benzamide
  • 3,4-difluoro-N-[2-(4-fluorophenyl)-2-(4-methylpiperazin-1-yl)ethyl]benzamide
  • Ethyl 6-oxo-4-((thiophen-2-ylsulfonyl)oxy)-1-(o-tolyl)-1,6-dihydropyridazine-3-carboxylate
  • 3-bromo-N-propylpropanamide
  • Ethyl 1-(2-chlorophenyl)-6-oxo-4-((thiophen-2-ylsulfonyl)oxy)-1,6-dihydropyridazine-3-carboxylate
  • Ethyl 4-(((5-ethylthiophen-2-yl)sulfonyl)oxy)-6-oxo-1-(p-tolyl)-1,6-dihydropyridazine-3-carboxylate
  • 4-ethoxy-N-[2-(4-fluorophenyl)-2-(4-methylpiperazin-1-yl)ethyl]benzamide
  • 4-chloro-N-(2-(4-fluorophenyl)-2-(4-methylpiperazin-1-yl)ethyl)benzamide
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