1-Chloro-2-naphthol

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Names

[ CAS No. ]:
633-99-8

[ Name ]:
1-Chloro-2-naphthol

[Synonym ]:
chloro-2-naphthol
1-chloro-2-naphthol
2-Naphthalenol,1-chloro
2-NAPHTHOL,1-CHLORO
1-Chloro-2-Naphthalenol
1-chloro-naphthalen-2-ol
1-chloronaphthalene-2-ol
1-chloro-2-naphtol
1-Chloro-2-hydroxynaphthalene

Chemical & Physical Properties

[ Density]:
1.333g/cm3

[ Boiling Point ]:
306.5ºC at 760 mmHg

[ Melting Point ]:
70ºC

[ Molecular Formula ]:
C10H7ClO

[ Molecular Weight ]:
178.61500

[ Flash Point ]:
139.2ºC

[ Exact Mass ]:
178.01900

[ PSA ]:
20.23000

[ LogP ]:
3.19880

[ Index of Refraction ]:
1.684

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QL3410000
CHEMICAL NAME :
2-Naphthol, 1-chloro-
CAS REGISTRY NUMBER :
633-99-8
BEILSTEIN REFERENCE NO. :
1939233
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C10-H7-Cl-O
MOLECULAR WEIGHT :
178.62
WISWESSER LINE NOTATION :
L66J BG CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2310 mg/kg
TOXIC EFFECTS :
Behavioral - withdrawal Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 32(4),55,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
580 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 32(4),55,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
275 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IJPAAO Indian Journal of Pharmacy. (Bombay, India) V.1-40(1), 1939-78. For publisher information, see IJSIDW. Volume(issue)/page/year: 30,89,1968

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Naphthol
  • 1-Naphthalenol
  • 1-diazo-2(1H)-naphthalenone
  • 2-Hydroxy-1-naphthoic acid
  • Ethanol
  • 2-Hydroxy-naphthaldehyde
  • 1,1'-Thio-bis-(2-naphthol)
  • 1-Chloronaphthalene
  • 2-Methoxynaphthalene
  • NAPHTHALENE, 1-CHLORO-2-METHOXY-

DownStream

  • 1-Nitro-2-naphthol
  • 1,2-NAPHTHOQUINONE
  • NAPHTHALENE, 1-CHLORO-2-METHOXY-
  • 1-(5-chloro-6-methoxynaphthalen-2-yl)ethanone
  • 6-Bromo-1-chloro-2-naphthol
  • 2-Naphthol
  • Para Red
  • 1,1'-Thio-bis-(2-naphthol)
  • 1,2-dichloronaphthalene
  • 2-methoxy-1-phenylnaphthalene

Related Compounds

  • 6-Bromo-1-chloro-2-naphthol
  • 6-(1,1-Dimethylethyl)-1-chloro-2-naphthol
  • 1-Chloro-4-(4-morpholinyl)-2-naphthol
  • 1-chloro-2-dichlorophosphoryl-1-methylsulfanylethene
  • 1-chloro-2-methylpent-2-ene
  • 1-chloro-2-(difluoromethoxy)-1,1,2-trifluoroethane
  • (1S,2S)-2-[(5-chloro-2-methoxyphenyl)amino]cyclopentan-1-ol
  • (1S,2S)-2-(1,4-diazepan-1-yl)cyclohexan-1-ol
  • Tert-butyl 4-(2-formylpropan-2-yl)piperidine-1-carboxylate
  • (2S)-4-(4-tert-butylphenyl)butan-2-ol
  • 1-Acetyl-3,4-didehydro-L-proline
  • 6-Isopropoxyimidazo[1,2-a]pyridine
  • 4-bromo-N-(1-cyanocyclopropyl)-3-nitrobenzenesulfonamide
  • 1-Methyl-1,2,3,4-tetrahydropyrazino[2,3-b]pyrazine
  • 4-Fluoro-2-iodo-5-(trifluoromethoxy)phenol
  • tert-butyl N-(2-hydroxy-5-phenylpentyl)carbamate
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