1,2,3,4-Tetrahydroquinoline

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Names

[ CAS No. ]:
635-46-1

[ Name ]:
1,2,3,4-Tetrahydroquinoline

[Synonym ]:
Kusol
Quinoline, 1,2,3,4-tetrahydro-
(1H)-tetrahydroquinoline
MFCD00006693
2,3,4-trihydroquinoline
Quinoline,1,2,3,4-tetrahydro
1,2,3,4-tetrahydro-quinoline
benzopiperidine
1,3,9,9a-tetrahydroquinoline
tetrahydroquinoline
EINECS 211-237-6
1,2,3,4-Tetrahydroquinoline

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
250.8±10.0 °C at 760 mmHg

[ Melting Point ]:
9-14 °C(lit.)

[ Molecular Formula ]:
C₉H₁₁N

[ Molecular Weight ]:
133.190

[ Flash Point ]:
100.6±0.0 °C

[ Exact Mass ]:
133.089142

[ PSA ]:
12.03000

[ LogP ]:
2.29

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.544

[ Storage condition ]:
Room temperature.

[ Water Solubility ]:
<1 g/L (20 ºC)

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H319-H335-H350

[ Precautionary Statements ]:
P201-P261-P305 + P351 + P338-P308 + P313

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29334990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

leucoline
1-prop-2-enyl-3,4-dihydro-2H-quinoline
(E)-2,3-dihydro-1H-inden-1-one oxime
3,4-Dihydroquinolin-2(1H)-one
quinoline 1-oxide
3-(2-Bromophenyl)-1-propanamine
3-(2-Chloro-phenyl)-propylamine
1,2,3,4-Tetrahydro-1-(p-tolylsulfonyl)quinoline
(E)-2,3-dihydro-1H-inden-1-oneO-methylsulfonyl oxime

DownStream

1-(4,6-dichloro-1,3,5-triazin-2-yl)-3,4-dihydro-2H-quinoline
3,4-dihydro-1H-isoquinolin-2-ylmethyl(trimethyl)silane
tert-Butyl 7-amino-3,4-dihydroquinoline-1(2H)-carboxylate
1,2,3,4-Tetrahydroquinoline-6-carboxylic acid
2-(3,4-DIHYDRO-2H-QUINOLIN-1-YL)-ETHYLAMINE
5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-1,2-dione
Quinolin-7-amine
Gentisic acid
Oxalic acid

Customs

[ HS Code ]: 29334990

Articles

Discovery of thienoquinolone derivatives as selective and ATP non-competitive CDK5/p25 inhibitors by structure-based virtual screening.

Bioorg. Med. Chem. 22(22) , 6409-21, (2014)

Calpain mediated cleavage of CDK5 natural precursor p35 causes a stable complex formation of CDK5/p25, which leads to hyperphosphorylation of tau. Thus inhibition of this complex is a viable target fo...

Pharmacokinetic plasma behaviors of intravenous and oral bioavailability of thymoquinone in a rabbit model.

Eur. J. Drug Metab. Pharmacokinet. 40 , 319-23, (2015)

Thymoquinone (THQ), the active constituent of Nigella sativa seeds, has demonstrated some potential pharmacological activities. The present study was designed to investigate the pharmacokinetic behavi...