L-2-Hydroxyglutaric acid disodium

Names

[ Name ]:
L-2-Hydroxyglutaric acid disodium

[Synonym ]:
Pentanedioic acid, 2-hydroxy-, sodium salt (1:2)
(2S)-2-Hydroxyglutaric Acid Disodium Salt
Disodium 2-hydroxypentanedioate

Chemical & Physical Properties

[ Melting Point ]:
>300ºC

[ Molecular Formula ]:
C₅H₆Na₂O₅

[ Molecular Weight ]:
192.078

[ Exact Mass ]:
192.001068

[ PSA ]:
100.49000

[ Storage condition ]:
−20°C

MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Validation of a hypoxia-inducible factor-1 alpha specimen collection procedure and quantitative enzyme-linked immunosorbent assay in solid tumor tissues.

Anal. Biochem. 459 , 1-11, (2014)

Hypoxia-inducible factor-1 alpha (HIF-1α) is an important marker of hypoxia in human tumors and has been implicated in tumor progression. Drugs targeting HIF-1α are being developed, but the ability to...

Prognostic significance of 2-hydroxyglutarate levels in acute myeloid leukemia in China.

Proc. Natl. Acad. Sci. U. S. A. 110(42) , 17017-22, (2013)

The 2-hydroxyglutarate (2-HG) has been reported to result from mutations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) genes and to function as an "oncometabolite." To evaluate the clinical sign...

Serum 2-hydroxyglutarate production in IDH1- and IDH2-mutated de novo acute myeloid leukemia: a study by the Acute Leukemia French Association group.

J. Clin. Oncol. 32(4) , 297-305, (2014)

Mutated isocitrate dehydrogenases (IDHs) 1 and 2 produce high levels of 2-hydroxyglutarate (2-HG). We investigated whether, in acute myeloid leukemia (AML), serum 2-HG would predict the presence of ID...

L-2-Hydroxyglutaric acid disodium

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Names

Chemical & Physical Properties

MSDS

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Safety Information

Articles

Related Compounds