4-Hydroxyisophthalic acid

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Names

[ CAS No. ]:
636-46-4

[ Name ]:
4-Hydroxyisophthalic acid

[Synonym ]:
4-Hydroxyisophthalic acid
MFCD00010391
4-Hydroxy-1,3-benzenedecarboxylic acid
1,3-Benzenedicarboxylic acid, 4-hydroxy-
4-Hydroxybenzene-1,3-dicarboxylic acid
EINECS 211-258-0

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
447.5±40.0 °C at 760 mmHg

[ Melting Point ]:
>300°C

[ Molecular Formula ]:
C8H6O5

[ Molecular Weight ]:
182.130

[ Flash Point ]:
238.6±23.8 °C

[ Exact Mass ]:
182.021530

[ PSA ]:
94.83000

[ LogP ]:
2.09

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.666

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NT2544000
CHEMICAL NAME :
Isophthalic acid, 4-hydroxy-
CAS REGISTRY NUMBER :
636-46-4
BEILSTEIN REFERENCE NO. :
2211981
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C8-H6-O5
MOLECULAR WEIGHT :
182.14

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1071 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 11,20,1956
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 16,200,1961 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
73500 mg/kg/14W-C
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 11,20,1956

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
NT2544000

[ HS Code ]:
2918290000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Bromoisophthalic acid
  • 4-phenylmethoxybenzene-1,3-dicarboxylic acid
  • 4-Nitrobenzonitrile
  • Ethyl 4-nitrobenzoate
  • sodium carbonate
  • carbon monoxide
  • 5-Iodosalicylic acid
  • 4-Methoxyisophthalic acid
  • Carbon dioxide

DownStream

  • Trinitrophenol
  • 5-Formyl-2-hydroxybenzoic acid
  • Dimethyl 4-hydroxyisophthalate
  • 2-hydroxy-5-(Methoxycarbonyl)benzoic acid
  • 4-carboxy-2-methoxycarbonylphenolate
  • Dimethyl 4-methoxyisophthalate
  • 2,4,4,6-tetrabromo-2,5-cyclohexadienone
  • Carbon dioxide
  • Salicylic acid

Customs

[ HS Code ]: 2918290000

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

Articles

A catabolic plasmid involved in 4-methyl-o-phthalate and 4-hydroxy-iso-phthalate degradation in Pseudomonas cepacia.

FEMS Microbiol. Lett. 57(3) , 323-8, (1990)

Genes involved in 4-methyl-o-phthalate and 4-hydroxy-iso-phthalate catabolism reside on a 226-232 kbp catabolic plasmid termed MOP. This was confirmed by transformation and conjugation into an isogeni...

[In vitro study of the mechanism of the platelet anti-aggregant action of picotamide (G 137)].

Boll. Soc. Ital. Biol. Sper. 59(3) , 309-15, (1983)

[In vitro study of the effects of various 4-hydroxyisophthalic acid derivatives on human platelet aggregation].

Boll. Soc. Ital. Biol. Sper. 59(3) , 302-8, (1983)


More Articles

Related Compounds

  • 5-sec-Butyl-4-hydroxyisophthalic acid
  • 4-Hydroxyisophthalic acid disodium salt
  • 4-Hydroxyisophthalic acid,diethyl ester
  • 4-Hydroxyisophthalic acid dimethyl ester
  • 4-Hydroxyisophthalic acid,compound with 1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one
  • 4-Hydroxyisophthalic acid,compound with 4-amino-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one (1:1)
  • 4-[Cyclopropyl(prop-2-yn-1-yl)amino]pyridine-3-carboxylic acid
  • 2-(cyclopropylmethyl)-3-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hex-4-ynamido]propanoic acid
  • 2-[1-(2-methylpropyl)-1H-pyrazol-5-yl]prop-2-en-1-amine
  • 2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-N-(propan-2-yl)hex-4-ynamido]acetic acid
  • 4-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-N-methylhex-4-ynamido]butanoic acid
  • 2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanamido]hex-4-ynoic acid
  • 4-[2-(Methoxymethyl)-1,3-thiazol-4-yl]but-3-en-2-amine
  • 2-{2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethoxy]acetamido}hex-4-ynoic acid
  • 1-(3,5-Dimethylphenyl)-4-prop-2-ynylpiperazine-2,3-dione
  • Benzonitrile, 2-[[4-(phenylmethoxy)phenyl]amino]-4-[4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-3-(trifluoromethyl)-1H-indazol-1-yl]-
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