Indobufen
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Names
[ CAS No. ]:
63610-08-2
[ Name ]:
Indobufen
[Synonym ]:
4-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-α-ethyl-benzeneacetic acid
Benzeneacetic acid, 4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-α-ethyl-, (±)-
(±)-4-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-a-ethylbenzeneacetic Acid
2-[4-(1-Oxo-1,3-dihydro-isoindol-2
MFCD00572250
2-[4-(1-Oxo-1,3-dihydro-2H-isoindol-2-yl)phenyl]butanoic acid
Benzeneacetic acid, 4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-α-ethyl-
K-3920
UNII-6T9949G4LZ
1-Oxo-2-[p-[(a-ethyl)carboxymethyl]phenyl]isoindoline
EINECS 264-364-4
2-(4-(1-Oxo-2-isoindolinyl)phenyl)butyric acid
Ibustrin
1-Oxo-2-(p-((α-ethyl)carboxymethyl)phenyl)isoindoline
2-[4-(1-Carboxypropyl)phenyl]-1-isoindolinone
(±)-2-[p-(1-Oxo-2-isoindolinyl)phenyl]butyric Acid
Butyric acid, 2-(p-(1-oxo-2-isoindolinyl)phenyl)-, (±)-
Indobufen
2-[4-(1-oxo-1,3-dihydro-isoindol-2-yl)-phenyl]-butyric acid
2-(4-(1-oxoisoindolin-2-yl)phenyl)butanoic acid
Indobufen (INN)
(±)-2-(p-(1-Oxo-2-isoindolinyl)phenyl)butyric acid
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
518.1±50.0 °C at 760 mmHg
[ Melting Point ]:
33-34 °C(lit.)
[ Molecular Formula ]:
C18H17NO3
[ Molecular Weight ]:
295.33
[ Flash Point ]:
267.1±30.1 °C
[ Exact Mass ]:
295.120850
[ PSA ]:
57.61000
[ LogP ]:
3.30
[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C
[ Index of Refraction ]:
1.630
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- ET5955800
- CHEMICAL NAME :
- Butyric acid, 2-(p-(1-oxo-2-isoindolinyl)phenyl)-, (+-)-
- CAS REGISTRY NUMBER :
- 63610-08-2
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C18-H17-N-O3
- MOLECULAR WEIGHT :
- 295.36
- WISWESSER LINE NOTATION :
- T56 BVN DHJ CR DY2&VQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 373 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,109,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 345 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,109,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 333 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,109,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 697 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,109,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 365 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,109,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 370 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,109,1979
Safety Information
[ WGK Germany ]:
3
[ HS Code ]:
2942000000
Customs
[ HS Code ]: 2918300090
[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%