Indobufen

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Names

[ CAS No. ]:
63610-08-2

[ Name ]:
Indobufen

[Synonym ]:
4-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-α-ethyl-benzeneacetic acid
Benzeneacetic acid, 4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-α-ethyl-, (±)-
(±)-4-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-a-ethylbenzeneacetic Acid
2-[4-(1-Oxo-1,3-dihydro-isoindol-2
MFCD00572250
2-[4-(1-Oxo-1,3-dihydro-2H-isoindol-2-yl)phenyl]butanoic acid
Benzeneacetic acid, 4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-α-ethyl-
K-3920
UNII-6T9949G4LZ
1-Oxo-2-[p-[(a-ethyl)carboxymethyl]phenyl]isoindoline
EINECS 264-364-4
2-(4-(1-Oxo-2-isoindolinyl)phenyl)butyric acid
Ibustrin
1-Oxo-2-(p-((α-ethyl)carboxymethyl)phenyl)isoindoline
2-[4-(1-Carboxypropyl)phenyl]-1-isoindolinone
(±)-2-[p-(1-Oxo-2-isoindolinyl)phenyl]butyric Acid
Butyric acid, 2-(p-(1-oxo-2-isoindolinyl)phenyl)-, (±)-
Indobufen
2-[4-(1-oxo-1,3-dihydro-isoindol-2-yl)-phenyl]-butyric acid
2-(4-(1-oxoisoindolin-2-yl)phenyl)butanoic acid
Indobufen (INN)
(±)-2-(p-(1-Oxo-2-isoindolinyl)phenyl)butyric acid

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
518.1±50.0 °C at 760 mmHg

[ Melting Point ]:
33-34 °C(lit.)

[ Molecular Formula ]:
C18H17NO3

[ Molecular Weight ]:
295.33

[ Flash Point ]:
267.1±30.1 °C

[ Exact Mass ]:
295.120850

[ PSA ]:
57.61000

[ LogP ]:
3.30

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.630

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ET5955800
CHEMICAL NAME :
Butyric acid, 2-(p-(1-oxo-2-isoindolinyl)phenyl)-, (+-)-
CAS REGISTRY NUMBER :
63610-08-2
LAST UPDATED :
199710
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C18-H17-N-O3
MOLECULAR WEIGHT :
295.36
WISWESSER LINE NOTATION :
T56 BVN DHJ CR DY2&VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
373 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,109,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
345 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,109,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
333 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,109,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
697 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,109,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
365 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,109,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
370 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,109,1979

Safety Information

[ WGK Germany ]:
3

[ HS Code ]:
2942000000

Customs

[ HS Code ]: 2918300090

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Related Compounds

  • indobufen
  • INDOBUFEN,D
  • Indobufen Impurity 3
  • Indobufen Impurity 9
  • 1,3-Dimethoxy-2-(Pyrid-2-yl)benzene
  • N-cyclopentyl-2-(5-(4-fluorophenyl)isoxazol-3-yl)acetamide
  • 2-(5-(4-Fluorophenyl)isoxazol-3-yl)-1-(indolin-1-yl)ethanone
  • 1-(2,1,3-benzothiadiazol-4-ylsulfonyl)-N-(2-methoxyethyl)-3-piperidinecarboxamide
  • 2-[[2-(1,3-Dioxolan-2-ylmethyl)phenyl]methyl]-1,3-dioxolane
  • 7-(Dimethylamino)-2,3-dihydro-4(1H)-quinolinone
  • 3,4-Dihydro-6-methoxy-4-phenyl-2(1H)-quinolinone
  • 3-(cyclopropylamino)dihydrofuran-2(3H)-one
  • 3-(2,3-dihydro-1H-inden-4-yl)propan-1-ol
  • 3-(5-Indanyl)-1-propanol
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