N(delta)-(N-methyl-N-nitrosocarbamoyl)-L-ornithine

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Names

[ Name ]:
N(delta)-(N-methyl-N-nitrosocarbamoyl)-L-ornithine

[Synonym ]:
N(sup 5)-(Methylnitrosocarbamoyl)-L-ornithine
N-(N-Methyl-N-nitrosocarbamoyl)-l-ornithine
n5-[methyl(nitroso)carbamoyl]-l-ornithine
L-Ornithine,N(5)-((methylnitrosoamino)carbonyl)
N5-((Methylnitrosoamino)carbonyl)-L-ornithine
MNCO

Chemical & Physical Properties

[ Molecular Formula ]:
C₇H₁₄N₄O₄

[ Molecular Weight ]:
218.21000

[ Exact Mass ]:
218.10200

[ PSA ]:
128.58000

[ LogP ]:
0.40600

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RM2983000

CHEMICAL NAME :: L-Ornithine, N(sup 5)-(N-methyl-N-nitrosocarbamoyl)-,

CAS REGISTRY NUMBER :: 63642-17-1

LAST UPDATED :: 199310

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C7-H14-N4-O4

MOLECULAR WEIGHT :: 218.25

WISWESSER LINE NOTATION :: QVYZ3MVN1&NO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1870 mg/kg/26W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 2616 mg/kg/12W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 3924 mg/kg/6W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 1308 mg/kg/6W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: DNA damage

MUTATION DATA

TEST SYSTEM :: Rodent - hamster

DOSE/DURATION :: 25 mg/kg

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 8,1033,1987 *** REVIEWS *** TOXICOLOGY REVIEW APLMAS Archives of Pathology and Laboratory Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-5(2), 1926-28; V.100- 1976- Volume(issue)/page/year: 107,54,1983

Safety Information

[ HS Code ]:
2924199090

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

N-[N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)aminocarbonyl]-L-valine lithium salt
N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)carbonyl)-L-valine methyl ester
L-Alanine,N-[N-methyl-N-[(phenylmethoxy)carbonyl]glycyl]- (9CI)
N-alpha-FMoc-N-delta-Methyl-L-glutaMine
L-Leucine,N-[N-methyl-N-[(phenylmethoxy)carbonyl]glycyl]-, methyl ester (9CI)
N-delta-chloroacetyl-L-ornithine
1-(2-Bromoethyl)-4-(2-methylbutan-2-yl)cyclohexan-1-ol
[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (3S,4aR,6aR,6aS,6bR,8aR,10S,12aR,14bS)-3,10-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate
N-(1-Iminoethyl)-2,2-dimethylpropanamide
1-Chloro-2,2,4,5,5-pentamethylhexane
5-(3-Fluoro-5-methylphenyl)-1,2-oxazol-4-amine
6-Amino-5-iodo-2-methyl-1(2H)-isoquinolinone
2-(Pyrrolidin-3-yloxy)-6-(thiophen-3-yl)pyridine
2-{1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoyl]piperidin-4-yl}acetic acid
3-({2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)propanoic acid
(2R)-1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanoyl]piperidine-2-carboxylic acid

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