(R)-Baclofen (hydrochloride)

Names

[ CAS No. ]:
63701-55-3

[ Name ]:
(R)-Baclofen (hydrochloride)

[Synonym ]:
Arbaclofen HCl
d-Baclofen hydrochloride
MFCD00078579
Arbaclofen hydrochloride
(R)-Baclofen (hydrochloride)

Chemical & Physical Properties

[ Boiling Point ]:
364.3ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₃Cl₂NO₂

[ Molecular Weight ]:
250.12200

[ Flash Point ]:
174.1ºC

[ Exact Mass ]:
249.03200

[ PSA ]:
63.32000

[ LogP ]:
3.35930

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MW5084350

CHEMICAL NAME :: Hydrocinnamic acid, beta-(aminomethyl)-p-chloro-, hydrochloride, (R)-

CAS REGISTRY NUMBER :: 63701-55-3

LAST UPDATED :: 198503

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H12-Cl-N-O2.Cl-H

MOLECULAR WEIGHT :: 250.14

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 523 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 32,187,1980

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
UN 2811 6.1/PG 3

[ RTECS ]:
MW5084350

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(4R)-4-(4-chlorophenyl)pyrrolidin-2-one
(R)-baclofen
(3S,4R)-4-(4-chlorophenyl)-2-oxopyrrolidine-3-carboxylic acid ethyl ester
(R)-4-azido-3-(4-chlorophenyl)butanoic acid
ethyl 4-azido-3-(4-chlorophenyl)-2-butenoate
p-chloro-beta-nitrostyrene
4-Chlorobenzaldehyde
(R)-ethyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-chlorophenyl)butanoate

DownStream

Articles

Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat.

Eur. J. Pharmacol. 196 , 267, (1991)

In a previous study it was found that i.t. administration of L-baclofen decreased arterial pressure and heart rate while D-baclofen differentially increased arterial pressure. The objective of the pre...

Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations.

J. Neurochem. 47 , 898, (1986)

The affinities of a number of analogues of gamma-aminobutyric acid (GABA) for GABAA and GABAB receptor sites and GABA uptake were studied using rat brain membrane preparations. Studies on the (S)-(+)-...

3-(p-Chlorophenyl)-4-aminobutanoic acid--resolution into enantiomers and pharmacological activity.

Pol. J. Pharmacol. Pharm. 32 , 187, (1980)

Racemic 3-(p-chlorophenyl)-4-aminobutanoic acid was resolved into enantiomers and their absolute configuration determined. Pharmacological activity of hydrochlorides of the racemic acid and its enanti...