N-(3-Amino-4-methylphenyl)acetamide

Names

[ Name ]:
N-(3-Amino-4-methylphenyl)acetamide

[Synonym ]:
4-acetylamino-2-aminotoluene
5-Acetylamino-o-toluidine
3'-Amino-p-acetotoluidide
N-(3-amino-4-methylphenyl)acetamide(SALTDATA: FREE)

Chemical & Physical Properties

[ Density]:
1.109g/cm3

[ Boiling Point ]:
645.4ºC at 760 mmHg

[ Molecular Formula ]:
C₉H₁₂N₂O

[ Molecular Weight ]:
164.20400

[ Flash Point ]:
213.5ºC

[ Exact Mass ]:
164.09500

[ PSA ]:
55.12000

[ LogP ]:
2.18980

[ Index of Refraction ]:
1.605

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AD8580000

CHEMICAL NAME :: Acetanilide, 3'-amino-4'-methyl-

CAS REGISTRY NUMBER :: 6375-16-2

BEILSTEIN REFERENCE NO. :: 2804114

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H12-N2-O

MOLECULAR WEIGHT :: 164.23

WISWESSER LINE NOTATION :: ZR B1 EMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 400 ug/plate

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 33,4556,1985

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
AD8580000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Acetamide,N-(4-methyl-3-nitrophenyl)-
2,4-Diaminotoluene
acetic acid
3-NITRO-4-TOLUIDINE
Acetamide
2,4-Dinitrotoluene

DownStream

N-(8-methyl-4-phenylquinolin-5-yl)acetamide
5-Amino-2-methylphenol
2,5-Benzothiazolediamine,6-methyl-(9CI)
fluoridamid
N-(3-hydroxy-4-methylphenyl)acetamide
ethyl N-(5-amino-2-methylphenyl)carbamate

Articles

Evidence for an acetoxyarylamine as the ultimate mutagenic reactive intermediate of the carcinogenic aromatic amine 2,4-diaminotoluene.

Mutat. Res. 242(2) , 101-10, (1990)

2,4-Diaminotoluene (2,4-DAT) is a mutagenic and hepatocarcinogenic aromatic amine, requiring metabolic activation. We have found that the mutagenic potency of 2,4-DAT in Salmonella TA98 is similar whe...

Comparison of the metabolism of 2,4-toluenediamine in rats and mice.

J. Environ. Pathol. Toxicol. 3(1-2) , 149-66, (1979)

The excretion, distribution, and metabolism of 2,4-toluenediamine (TDA) have been compared in rats and mice. The elimination of TDA metabolites into urine was faster and more complete in mice than in ...

Gas chromatographic/tandem mass spectrometric identification and quantitation of metabolic 4-acetyltoluene-2,4-diamine from the F344 rat.

Biol. Mass Spectrom. 22(3) , 194-200, (1993)

2,4-Toluenediamine (TDA) and 2,4-toluenediisocyanate (TDI) are metabolized in the Fischer 344 rat to monoacetyl-2,4-toluenediamine (Ac-TDA) and diacetyl-2,4-toluenediamine (Ac2-TDA). A gas chromatogra...

N-(3-amino-4-methylphenyl)acetamide,hydrochloride
N-(3-amino-4-methylphenyl)-2-(dimethylamino)acetamide
N-[(3-amino-4-methylphenyl)methyl]-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide
N-(3-amino-4-methylphenyl)methanesulfonamide(SALTDATA: HCl)
N-(3-Amino-4-methylphenyl)isonicotinamide
N-(3-amino-4-methylphenyl)-3-bromobenzamide
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
O-(4-methoxy-2-methylbutan-2-yl)hydroxylamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
1-(Cyclopropylamino)hexan-2-one
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine