6-Chloromelatonin

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Names

[ CAS No. ]:
63762-74-3

[ Name ]:
6-Chloromelatonin

[Synonym ]:
Tocris-0443
6-CHLOROMELATONIN
6-Cl-melatonin
Lopac-C-0331

Chemical & Physical Properties

[ Density]:
1.272g/cm3

[ Boiling Point ]:
536.7ºC at 760 mmHg

[ Molecular Formula ]:
C13H15ClN2O2

[ Molecular Weight ]:
266.72300

[ Flash Point ]:
278.4ºC

[ Exact Mass ]:
266.08200

[ PSA ]:
54.12000

[ LogP ]:
2.89940

[ Index of Refraction ]:
1.608

[ Storage condition ]:
-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AB5750000
CHEMICAL NAME :
Acetamide, N-(2-(6-chloro-5-methoxy-1H-indol-3-yl)ethyl)-
CAS REGISTRY NUMBER :
63762-74-3
BEILSTEIN REFERENCE NO. :
0410191
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C13-H15-Cl-N2-O2
MOLECULAR WEIGHT :
266.75
WISWESSER LINE NOTATION :
T56 BMJ D2MV1 GO1 HG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
4 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 22,63,1979
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
4 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 22,63,1979
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
1260 ug/kg
SEX/DURATION :
female 9 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 78,381,1986

Safety Information

[ Hazard Codes ]:
T

[ Risk Phrases ]:
60-23/24/25-36/37/38

[ Safety Phrases ]:
53-26-36/37/39-45

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Chloro-5-methylphenol
  • 2-CHLORO-5-METHYL-4-NITROPHENOL
  • 1-Chloro-2-methoxy-4-methyl-5-nitrobenzene
  • 2-chloro-5-[(β-dimethylamino)-vinyl]-4-nitroanisole
  • 6-Chloro-5-methoxy-1H-indole

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 6-Chloromelatonin
  • B-METHYL-6-CHLOROMELATONIN
  • 6-chloro-3-[[ethoxy(ethylsulfanyl)phosphoryl]sulfanylmethyl]-1,3-benzoxazol-2-one
  • 6-Chloro-N-(3-pyridinylmethyl)-4-pyrimidinamine
  • 6-chloro-3,3,4,4,5,5,6,6-octafluorohexan-1-ol
  • 6-bromo-3-chloroquinoxalin-2-amine