m-Toluidine Hydrochloride

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Names

[ CAS No. ]:
638-03-9

[ Name ]:
m-Toluidine Hydrochloride

[Synonym ]:
M-TOLUIDINE HYDROCHLORIDE
m-toluidinium chloride
3-methylanilinium chloride
Benzenamine,3-methyl-,hydrochloride
m-Toluidin-hydrochlorid
3-Toluidinhydrochlorid
MFCD00070607
EINECS 211-314-4
3-Methylaniline hydrochloride
m-Toluidine.HCl

Chemical & Physical Properties

[ Boiling Point ]:
250ºC ()

[ Melting Point ]:
228ºC

[ Molecular Formula ]:
C7H10ClN

[ Molecular Weight ]:
143.61400

[ Exact Mass ]:
143.05000

[ PSA ]:
26.02000

[ LogP ]:
2.96040

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XU7175000
CHEMICAL NAME :
m-Toluidine, hydrochloride
CAS REGISTRY NUMBER :
638-03-9
LAST UPDATED :
199707
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C7-H9-N.Cl-H
MOLECULAR WEIGHT :
143.63
WISWESSER LINE NOTATION :
ZR C1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
660 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 2(2),325,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
650 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCIBR* Progress Report for Contract No. NIH-NCI-E-68-1311, Submitted to the National Cancer Institute by Bio-Research Consultants, Inc. (9 Commercial Ave., Cambridge, MA 02141) Volume(issue)/page/year: NCI-E-68-1311,1973
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
574 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 130,250,1928 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
475 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 2(2),325,1978
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
950 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 2(2),325,1978

Safety Information

[ Hazard Codes ]:
T

[ RIDADR ]:
UN 2811 6.1/PG 3

[ HS Code ]:
2923900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3-Nitrotoluene
  • 3-Toluidine
  • 3-methoxy-N-(m-tolyl)-8-((m-tolylimino)methyl)-6,7-dihydro-5H-benzo[7]annulen-9-amine hydrochloride
  • 2,4-Dinitrochlorobenzene
  • Ethanol
  • 1,3-bis(3-methylphenyl)thiourea
  • Chloroacetic acid
  • Pyridine
  • 1-phenyl-1-m-toluidino-pentan-3-one
  • Phenylhydrazine hydrochloride

DownStream

  • 7-Methylbenzo[d]thiazol-2-amine
  • 1-(3-Methylphenyl)piperazine
  • N,N-Diethyl-m-toluidine
  • N-Ethyl-3-methylaniline
  • 2-methyl-3-(3-methylphenyl)quinazolin-4-one
  • 6-methyl-1,2,3,4-tetrahydroacridine
  • 3-Toluidine
  • 3,4-Dimethylaniline
  • 2,3,4,6-tetramethylaniline
  • 2,3,4,6-tetramethylphenol

Customs

[ HS Code ]: 2923900090

[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Related Compounds

  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 2-Allyl-1-methoxy-4-(methoxymethyl)benzene
  • 2-[1,1a(2)-Biphenyl]-3-yl-9,10-di-2-naphthalenylanthracene
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • Methyl 1-(2,2,2-trifluoroethyl)-1H-indazole-6-carboxylate
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde