m-Toluidine Hydrochloride

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Names

[ CAS No. ]:
638-03-9

[ Name ]:
m-Toluidine Hydrochloride

[Synonym ]:
M-TOLUIDINE HYDROCHLORIDE
m-toluidinium chloride
3-methylanilinium chloride
Benzenamine,3-methyl-,hydrochloride
m-Toluidin-hydrochlorid
3-Toluidinhydrochlorid
MFCD00070607
EINECS 211-314-4
3-Methylaniline hydrochloride
m-Toluidine.HCl

Chemical & Physical Properties

[ Boiling Point ]:
250ºC ()

[ Melting Point ]:
228ºC

[ Molecular Formula ]:
C₇H₁₀ClN

[ Molecular Weight ]:
143.61400

[ Exact Mass ]:
143.05000

[ PSA ]:
26.02000

[ LogP ]:
2.96040

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XU7175000

CHEMICAL NAME :: m-Toluidine, hydrochloride

CAS REGISTRY NUMBER :: 638-03-9

LAST UPDATED :: 199707

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C7-H9-N.Cl-H

MOLECULAR WEIGHT :: 143.63

WISWESSER LINE NOTATION :: ZR C1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 660 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 2(2),325,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCIBR* Progress Report for Contract No. NIH-NCI-E-68-1311, Submitted to the National Cancer Institute by Bio-Research Consultants, Inc. (9 Commercial Ave., Cambridge, MA 02141) Volume(issue)/page/year: NCI-E-68-1311,1973

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 574 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - other (direct) parasympathomimetic

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 130,250,1928 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 475 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

REFERENCE :: JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 2(2),325,1978

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 950 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

REFERENCE :: JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 2(2),325,1978

Safety Information

[ Hazard Codes ]:
T

[ RIDADR ]:
UN 2811 6.1/PG 3

[ HS Code ]:
2923900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

3-Nitrotoluene
3-Toluidine
3-methoxy-N-(m-tolyl)-8-((m-tolylimino)methyl)-6,7-dihydro-5H-benzo[7]annulen-9-amine hydrochloride
2,4-Dinitrochlorobenzene
Ethanol
1,3-bis(3-methylphenyl)thiourea
Chloroacetic acid
Pyridine
1-phenyl-1-m-toluidino-pentan-3-one
Phenylhydrazine hydrochloride

DownStream

7-Methylbenzo[d]thiazol-2-amine
1-(3-Methylphenyl)piperazine
N,N-Diethyl-m-toluidine
N-Ethyl-3-methylaniline
2-methyl-3-(3-methylphenyl)quinazolin-4-one
6-methyl-1,2,3,4-tetrahydroacridine
3-Toluidine
3,4-Dimethylaniline
2,3,4,6-tetramethylaniline
2,3,4,6-tetramethylphenol

Customs

[ HS Code ]: 2923900090

[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Related Compounds

1-(Aminomethyl)-2-oxa-7-thiaspiro[4.5]decan-3-one
2-hydroxy-3-[1-(2-methoxyethyl)-1H-imidazol-2-yl]propanoic acid
3-Amino-6,6,6-trifluoro-3-methylhexanamide
4-Formyl-2-sulfamoylbenzoic acid
1-[1-(4-Methylpyridin-2-yl)cyclopropyl]cyclopropan-1-amine
1-(2,2-difluoroethyl)-5-(1-methyl-1H-pyrazol-5-yl)-1H-1,2,3-triazol-4-amine
2-[(Azetidin-3-yl)methyl]-5-bromo-3-nitropyridine
2-cyclopropyl-2-{[6-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanamido]oxy}acetic acid
2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-N-(propan-2-yl)-3-(1H-pyrrol-2-yl)propanamido]acetic acid
1-[2-(cyclopropylmethyl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-N-methylpropanamido]cyclobutane-1-carboxylic acid

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