N-Methyl-D-aspartic acid

Suppliers

Names

[ CAS No. ]:
6384-92-5

[ Name ]:
N-Methyl-D-aspartic acid

[Synonym ]:
N-Methylaspartic acid
DL-Aspartic acid, N-methyl-
N-Methyl-DL-Aspartic acid
EINECS 227-012-0
DL-2-METHYLAMINOSUCCINIC ACID
D-Aspartic acid, N-methyl-
Aspartic acid, N-methyl-
N-Me-D-Asp-OH
(2R)-2-(methylamino)butanedioic acid
UNII:EU52DFC4WJ
NMDA
N-Methyl--aspartic acid
MFCD06795789
N-Methyl aspartic acid
N-Methyl-D-aspartic acid

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
258.2±30.0 °C at 760 mmHg

[ Melting Point ]:
187-192 °C

[ Molecular Formula ]:
C5H9NO4

[ Molecular Weight ]:
147.129

[ Flash Point ]:
110.0±24.6 °C

[ Exact Mass ]:
147.053162

[ PSA ]:
86.63000

[ LogP ]:
-0.44

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.494

[ Water Solubility ]:
slightly soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CI9457000
CHEMICAL NAME :
D-Aspartic acid, N-methyl-
CAS REGISTRY NUMBER :
6384-92-5
BEILSTEIN REFERENCE NO. :
1724431
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C5-H9-N-O4
MOLECULAR WEIGHT :
147.15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
137 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 269,573,1994

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
CI9457000

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • UNII:EU52DFC4WJ
  • N-methylaspartic acid dimethyl ester
  • H-D-Asp-OH
  • methyl iodide
  • Grassypeptolide A
  • Dimethyl sulfate

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Long-term application of glycine transporter inhibitors acts antineuropathic and modulates spinal N-methyl-D-aspartate receptor subunit NR-1 expression in rats.

Anesthesiology 121(1) , 160-9, (2014)

Dysfunction of spinal glycinergic neurotransmission is a major pathogenetic factor in neuropathic pain. The synaptic glycine concentration is controlled by the two glycine transporters (GlyT) 1 and 2....

Glutamatergic receptor dysfunction in spinal cord contributes to the exaggerated exercise pressor reflex in heart failure.

Am. J. Physiol. Heart Circ. Physiol. 308(5) , H447-55, (2015)

Excitatory amino acids (e.g., glutamate) released by contraction-activated skeletal muscle afferents into the dorsal horn of the spinal cord initiate the central component of the exercise pressor refl...

Cysteine substitution of transmembrane domain amino acids alters the ethanol inhibition of GluN1/GluN2A N-methyl-D-aspartate receptors.

J. Pharmacol. Exp. Ther. 353(1) , 91-101, (2015)

N-Methyl-d-aspartate receptors (NMDARs) are inhibited by behaviorally relevant concentrations of ethanol, and residues within transmembrane (TM) domains of NMDARs, including TM3 GluN1 phenylalanine 63...


More Articles

Related Compounds

  • N-Methyl-D-aspartic Acid Hydrate
  • UNII:EU52DFC4WJ
  • Fmoc-N-Me-D-Asp(OtBu)-OH
  • BOC-ALPHA-METHYL-D-ASPARTIC ACID
  • (3S)-3-Methyl-D-aspartic acid
  • (R)-(-)-2-Amino-2-methylbutanedioic Acid Hydrochloride Salt
  • 3,4,7a-Triazacyclohepta[jk]fluorene, 1,2,4,5,6,7-hexahydro-10-methoxy-4-methyl-
  • 4-Nitrophenyl (2S,4R)-4-(acetylthio)-2-(hydroxymethyl)-1-pyrrolidinecarboxylate
  • 2H-Pyran-4-methanamine, tetrahydro-2,6-dimethyl-N-(2-oxiranylmethyl)-, (2R,6S)-
  • Phenol, 4,4a(2),4a(2)a(2)-[1,3,5-benzenetriyltris(1-methylethylidene)]tris[2-cyclohexyl-
  • 2-[(4-Fluoro-2-hydroxyphenyl)(4-methoxyphenyl)methylene]hydrazinecarbothioamide
  • Benzeneacetamide, N-[2-[(benzoyloxy)amino]-1-(hydroxymethyl)-2-oxoethyl]-, (S)-
  • N-(4-Chlorophenyl)-6-(2-methylpropyl)-5-oxo-6-azaspiro[3.4]octane-7-carboxamide
  • 1,2,3,4-Tetrahydro-5,6,7-trimethoxy-2-methyl-4-oxo-1-naphthalenecarboxylic acid
  • Glucopyranoside, p-nitrophenyl 2-acetamido-2-deoxy-6-O-trityl-, diacetate, I(2)-D-
  • Benzenepropanoic acid, I(2)-amino-4-[(3-methoxyphenyl)amino]-, methyl ester, (I(2)S)-
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