2-[(4,5-diphenyl-1,3-oxazol-2-yl)-(2-hydroxyethyl)amino]ethanol,hydrate

Names

[ CAS No. ]:
63867-52-7

[ Name ]:
2-[(4,5-diphenyl-1,3-oxazol-2-yl)-(2-hydroxyethyl)amino]ethanol,hydrate

[Synonym ]:
S 222
Diethamphenazol monohydrate
Ageroplas
Ditazol monohydrate

Chemical & Physical Properties

[ Boiling Point ]:
505.5ºC at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₂N₂O₄

[ Molecular Weight ]:
342.38900

[ Flash Point ]:
259.5ºC

[ Exact Mass ]:
342.15800

[ PSA ]:
78.96000

[ LogP ]:
2.73530

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KK7400000

CHEMICAL NAME :: Ethanol, 2,2'-((4,5-diphenyl-2-oxazolyl)imino)di-, monohydrate

CAS REGISTRY NUMBER :: 63867-52-7

LAST UPDATED :: 199007

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C19-H20-N2-O3.H2-O

MOLECULAR WEIGHT :: 342.43

WISWESSER LINE NOTATION :: T5N COJ BN2Q2Q DR& ER &QH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 11380 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 23,1283,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7770 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 23,1283,1973

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2300 mg/kg

TOXIC EFFECTS :: Behavioral - analgesia Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,1092,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3390 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 23,1283,1973

Related Compounds

trans-N-Benzyl-2,6-dimethylpiperidin-4-one
4-(6-Methylimidazo[2,1-b]thiazol-5-yl)but-3-en-2-one
2-Fluoro-4-(furan-3-yl)benzoic acid
7-ethyl-3,4-dihydro-2H-isoquinolin-1-one
2-ethyl-4H,5H-thieno[3,2-c]pyridin-4-one
2-(((5-(3-Chloro-4-fluorophenyl)furan-2-yl)methyl)amino)acetic acid
ethyl (2R)-1,2,3,4-tetrahydroquinoline-2-carboxylate
Octahydropyrano[3,4-b]thiomorpholine
Ethyl 3-(2-fluoro-4-pyridinyl)-2-propenoate
1-(3,4-Difluorophenyl)-5-methyl-1,4-diazepane

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