4-[N-(2-Thiazolyl)sulfamoyl]-2-(anilinocarbonyl)benzoic acid sodium salt

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Names

[ Name ]:
4-[N-(2-Thiazolyl)sulfamoyl]-2-(anilinocarbonyl)benzoic acid sodium salt

[Synonym ]:
Phthalanilic acid,4'-(2-thiazolylsulfamoyl)-,sodium salt
Phthalylsulfathiazole,sodium salt
85-73-4 (Parent)
2-(N(sup 4)-Phthalylsulfanilamido)thiazole sodium salt
Sodium phthalylsulfathiazole

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₂N₃NaO₅S₂

[ Molecular Weight ]:
425.41400

[ Exact Mass ]:
425.01200

[ PSA ]:
164.91000

[ LogP ]:
2.78650

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TH8750000

CHEMICAL NAME :: Phthalanilic acid, 4'-(2-thiazolylsulfamoyl)-, sodium salt

CAS REGISTRY NUMBER :: 63868-70-2

LAST UPDATED :: 199607

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C17-H12-N3-O5-S2.Na

MOLECULAR WEIGHT :: 425.43

WISWESSER LINE NOTATION :: T5N CSJ BMSWR DMVR BVQ &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,116,1944 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 6 gm/kg/6D-I

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - other changes Related to Chronic Data - death

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,116,1944

Related Compounds

rac-2-({1-[(1R,2S)-2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclopentanecarbonyl]azetidin-3-yl}oxy)acetic acid
2-({1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)benzoyl]azetidin-3-yl}oxy)acetic acid
2-{[1-(2-{1-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclobutyl}acetyl)azetidin-3-yl]oxy}acetic acid
2-[(1-{1-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclopentanecarbonyl}azetidin-3-yl)oxy]acetic acid
2-({1-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclohexanecarbonyl]azetidin-3-yl}oxy)acetic acid
5-Methyl-6lambda6-thia-2,5-diazaspiro[3.4]octane-6,6,8-trione
(2S)-1-[(1RS,3RS)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclohexanecarbonyl]-2-methylpyrrolidine-2-carboxylic acid
(2R)-1-{2-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-1H-pyrazol-1-yl]acetyl}-2-methylpyrrolidine-2-carboxylic acid
3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-{[2-(1,2-thiazol-5-yl)ethyl]carbamoyl}propanoic acid
rac-2-{2-[(1R,2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclohexyl]-N-(prop-2-yn-1-yl)acetamido}acetic acid

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