1,2,3,4-Tetrahydro-isoquinolin-6-ol HCl

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Names

[ CAS No. ]:
63905-73-7

[ Name ]:
1,2,3,4-Tetrahydro-isoquinolin-6-ol HCl

[Synonym ]:
1,2,3,4-tetrahydroisoquinolin-6-ol Hydrochloride
1,2,3,4-Tetrahydro-isoquinolin-6-ol HCl
6-Isoquinolinol, 1,2,3,4-tetrahydro-, hydrochloride (1:1)
1,2,3,4-Tetrahydro-6-isoquinolinol hydrochloride (1:1)

Chemical & Physical Properties

[ Boiling Point ]:
313.5ºC at 760mmHg

[ Molecular Formula ]:
C9H12ClNO

[ Molecular Weight ]:
185.651

[ Flash Point ]:
169.5ºC

[ Exact Mass ]:
185.060745

[ PSA ]:
32.26000

[ LogP ]:
2.16870

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NX1400000
CHEMICAL NAME :
Isoquinoline, 6-hydroxy-1,2,3,4-tetrahydro-, hydrochloride
CAS REGISTRY NUMBER :
63905-73-7
LAST UPDATED :
199009
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C9-H11-N-O.Cl-H
MOLECULAR WEIGHT :
185.67
WISWESSER LINE NOTATION :
T66 CMT&J HQ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
465 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 62,165,1938

Safety Information

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 6-Methoxy-1,2,3,4-tetrahydroisochinolin
  • Formaldehyde
  • 3-HYDROXYPHENETHYLAMINE HYDROCHLORIDE

DownStream

  • tert-butyl 6-(trifluoromethylsulfonyloxy)-3,4-dihydro-1H-isoquinoline-2-carboxylate
  • 2-Tert-Butyl 6-Methyl 3,4-Dihydroisoquinoline-2,6(1H)-Dicarboxylate
  • 1,2,3,4-Tetrahydro-6-isoquinolinol
  • tert-Butyl 6-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate
  • N-BOC-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 5-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-OL
  • (s)-7-methoxy-1-methyl-1,2,3,4-tetrahydro-isoquinolin-6-ol
  • (R)-1-(4-hydroxy-benzyl)-7-methoxy-1,2,3,4-tetrahydro-isoquinolin-6-ol
  • 1-(4-hydroxy-3-methoxy-benzyl)-7-methoxy-1,2,3,4-tetrahydro-isoquinolin-6-ol
  • protosinomenine
  • (1,2,3,4-Tetrahydro-Isoquinolin-6-Yl)-Methanol
  • 1-(Cyclohexylmethyl)-2,3-dihydroindol-5-amine
  • Ethyl 2-amino-3,3-difluoro-3-phenylpropanoate
  • N-Acetyl-I(2),I(2)-difluorophenylalanine ethyl ester
  • 3-Isopropyl-5-methylpyridin-2-amine
  • 3-(4,4-Dimethylcyclohexyl)propan-1-ol
  • (2R,5R)-1-(11bR)-Dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl-2,5-di-1-naphthalenylpyrrolidine
  • 1-(2-chloro-2-phenylethyl)-N-(3-fluorophenethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
  • Methyl (2-bromo-4-methylphenyl)glycinate
  • Ethyl 2-[(pyridin-4-yl)amino]acetate
  • (Pyridin-3-yl)methyl 4-(2-nitro-5-(thiophen-2-yl)phenylcarbamoyl)benzylcarbamate
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