10H-Pyrido[3,2-b]pyrimido[4,5-e][1,4]thiazin-2-amine,4-chloro-8-methyl-

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Names

[ CAS No. ]:
63931-11-3

[ Name ]:
10H-Pyrido[3,2-b]pyrimido[4,5-e][1,4]thiazin-2-amine,4-chloro-8-methyl-

[Synonym ]:
2-Amino-4-chloro-8-methyl-1,3,9-triazaphenothiazine

Chemical & Physical Properties

[ Density]:
1.547g/cm3

[ Boiling Point ]:
551.3ºC at 760mmHg

[ Molecular Formula ]:
C10H8ClN5S

[ Molecular Weight ]:
265.72200

[ Flash Point ]:
287.2ºC

[ Exact Mass ]:
265.01900

[ PSA ]:
105.25000

[ LogP ]:
2.06250

[ Index of Refraction ]:
1.883

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV1173050
CHEMICAL NAME :
10H-Pyrido(3,2-b)pyrimido(4,2-e)(1,4)thiazin-2-amine, 4-chloro-8-methyl-
CAS REGISTRY NUMBER :
63931-11-3
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C10-H8-Cl-N5-S
MOLECULAR WEIGHT :
265.74

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
228 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 12,249,1977

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Amino-5-bromo-4,6-dichloropyrimidine
  • 2-amino-6-methylpyridine-3-thiol

DownStream

Related Compounds

  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 3-fluoro-4-methoxy-N-(2-(4-methylpiperazin-1-yl)-2-(thiophen-3-yl)ethyl)benzenesulfonamide
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • N-(2-fluorophenyl)-4-(6-oxo-3-phenylpyridazin-1(6H)-yl)butanamide
  • tert-Butyl-DL-alanine