10H-Pyrido[3,2-b]pyrimido[4,5-e][1,4]thiazin-2-amine,4-chloro-8-methyl-

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Names

[ CAS No. ]:
63931-11-3

[ Name ]:
10H-Pyrido[3,2-b]pyrimido[4,5-e][1,4]thiazin-2-amine,4-chloro-8-methyl-

[Synonym ]:
2-Amino-4-chloro-8-methyl-1,3,9-triazaphenothiazine

Chemical & Physical Properties

[ Density]:
1.547g/cm3

[ Boiling Point ]:
551.3ºC at 760mmHg

[ Molecular Formula ]:
C10H8ClN5S

[ Molecular Weight ]:
265.72200

[ Flash Point ]:
287.2ºC

[ Exact Mass ]:
265.01900

[ PSA ]:
105.25000

[ LogP ]:
2.06250

[ Index of Refraction ]:
1.883

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV1173050
CHEMICAL NAME :
10H-Pyrido(3,2-b)pyrimido(4,2-e)(1,4)thiazin-2-amine, 4-chloro-8-methyl-
CAS REGISTRY NUMBER :
63931-11-3
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C10-H8-Cl-N5-S
MOLECULAR WEIGHT :
265.74

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
228 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 12,249,1977

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Amino-5-bromo-4,6-dichloropyrimidine
  • 2-amino-6-methylpyridine-3-thiol

DownStream

Related Compounds

  • 2-{[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetamido]methyl}cyclohexane-1-carboxylic acid
  • 3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-[(4-hydroxy-2-methylbutyl)carbamoyl]propanoic acid
  • 4-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylpropanamido]-3-hydroxy-3-methylbutanoic acid
  • 3-[3-cyclopropyl-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanamido]-3-methylbutanoic acid
  • (2S)-3-cyclopropyl-2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanamido]propanoic acid
  • 3-cyclopropyl-2-{2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethoxy]acetamido}propanoic acid
  • 5-(3-Aminophenyl)-1,2,3,4-tetrahydroisoquinolin-8-amine
  • 2-(Piperidin-4-yl)piperidine-3-carboxylic acid
  • [6-(Piperidin-4-yl)piperidin-3-yl]methanamine
  • MurB-IN-1
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