4-chloro-N-(2-methylindol-1-yl)-3-sulfamoylbenzamide

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Names

[ CAS No. ]:
63968-75-2

[ Name ]:
4-chloro-N-(2-methylindol-1-yl)-3-sulfamoylbenzamide

[Synonym ]:
N-(3-sulfamyl-4-chlorobenzamido)-2-methylindole
4-Chloro-N-(2-methyl-1-indolyl)-3-sulfamoylbenzamide
Benzamide,3-(aminosulfonyl)-4-chloro-N-(2-methyl-1H-indol-1-yl)
BENZAMIDE,4-CHLORO-N-(2-METHYL-1-INDOLYL)-3-SULFAMOYL
Dehydroindapamide
Indapamide Impurity 2

Chemical & Physical Properties

[ Density]:
1.49g/cm3

[ Melting Point ]:
255-257℃

[ Molecular Formula ]:
C16H14ClN3O3S

[ Molecular Weight ]:
363.81900

[ Exact Mass ]:
363.04400

[ PSA ]:
102.57000

[ LogP ]:
4.48850

[ Index of Refraction ]:
1.687

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CV2451500
CHEMICAL NAME :
Benzamide, 4-chloro-N-(2-methyl-1-indolyl)-3-sulfamoyl-
CAS REGISTRY NUMBER :
63968-75-2
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C16-H14-Cl-N3-O3-S
MOLECULAR WEIGHT :
363.84

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,2275,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
620 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,2275,1982

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Indapamide
  • 2-methylindol-1-amine
  • 4-Chloro-3-sulfamoylbenzoyl chloride

DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Related Compounds

  • N-{4-[(4-{[(3-methylpyridin-2-yl)oxy]methyl}piperidin-1-yl)methyl]phenyl}acetamide
  • 1-{4-[(5-Fluoropyrimidin-2-yl)oxy]piperidin-1-yl}-2-phenoxyethan-1-one
  • N-cyclopentyl-4-[(4-oxo-3,4-dihydroquinazolin-3-yl)methyl]piperidine-1-carboxamide
  • 3-(4-{1,6-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl}piperazin-1-yl)-6-methylpyridazine
  • 3-Phenyl-1-(4-{[4-(trifluoromethyl)pyrimidin-2-yl]oxy}piperidin-1-yl)propan-1-one
  • 1-Methyl-4-[4-(6-methylpyridazin-3-yl)piperazin-1-yl]pyrazolo[3,4-d]pyrimidine
  • 1-cyclopropyl-3-[3-(2-cyclopropyl-1H-1,3-benzodiazol-1-yl)azetidin-1-yl]pyrrolidin-2-one
  • 2-(4-Fluorophenyl)-1-(4-{[4-(trifluoromethyl)pyrimidin-2-yl]oxy}piperidin-1-yl)ethan-1-one
  • 4-[(3,5-Dimethyl-1,2-oxazol-4-yl)sulfonyl]-1-[2-(trifluoromethyl)pyridin-4-yl]piperazin-2-one
  • 2-(2-Fluorophenoxy)-1-{4-[(5-methylpyrimidin-2-yl)oxy]piperidin-1-yl}propan-1-one
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