1,4-Piperazinedicarboxylicacid, 2-methyl-, 1,4-diethyl ester

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Names

[ CAS No. ]:
63981-45-3

[ Name ]:
1,4-Piperazinedicarboxylicacid, 2-methyl-, 1,4-diethyl ester

[Synonym ]:
1,4-Dicarbethoxy-2-methylpiperazine
2-Methyl-piperazin-1,4-dicarbonsaeure-diaethylester
1,4-Piperazinedicarboxylic acid,2-methyl-,diethyl ester
1,2-methyl-,diethyl ester
2-methyl-piperazine-1,4-dicarboxylic acid diethyl ester

Chemical & Physical Properties

[ Density]:
1.126g/cm3

[ Boiling Point ]:
323.5ºC at 760 mmHg

[ Molecular Formula ]:
C11H20N2O4

[ Molecular Weight ]:
244.28700

[ Flash Point ]:
149.5ºC

[ Exact Mass ]:
244.14200

[ PSA ]:
59.08000

[ LogP ]:
1.18130

[ Index of Refraction ]:
1.478

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TL3555000
CHEMICAL NAME :
1,4-Piperazinedicarboxylic acid, 2-methyl-, diethyl ester
CAS REGISTRY NUMBER :
63981-45-3
BEILSTEIN REFERENCE NO. :
0231581
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C11-H20-N2-O4
MOLECULAR WEIGHT :
244.33
WISWESSER LINE NOTATION :
T6N DNTJ AVO2 B1 DVO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
375 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Methylpiperazine
  • Ethyl chloroformate

DownStream

Related Compounds

  • tert-butyl N-(3-methoxy-2-sulfamoylphenyl)carbamate
  • tert-butyl N-{[(2S,4S)-4-fluoro-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrrolidin-2-yl]methyl}-N-methylcarbamate
  • tert-butyl N-{[(2S,4S)-4-fluoro-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrrolidin-2-yl]methyl}carbamate
  • tert-butyl N-{[(2S,4S)-4-fluoro-1-[(5-methyl-1,2-oxazol-4-yl)methyl]pyrrolidin-2-yl]methyl}carbamate
  • 2-[4-(2,2,2-Trifluoroacetyl)piperazin-1-yl]pentanoic acid
  • 3-{Methyl[1-(2,2,2-trifluoroacetyl)piperidin-4-yl]amino}propanoic acid
  • 3-[3-Methyl-5-(trifluoroacetamido)piperidin-1-yl]propanoic acid
  • rac-(3'aR,6'aR)-1-[(prop-2-en-1-yloxy)carbonyl]-hexahydrospiro[azetidine-3,1'-furo[3,4-c]pyrrole]-3'a-carboxylic acid
  • 3-Oxo-1-[(prop-2-en-1-yloxy)carbonyl]-decahydroquinoxaline-6-carboxylic acid
  • tert-butyl N-(2-ethoxy-5-nitrophenyl)carbamate
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