H-D-Val-OH

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Names

[ CAS No. ]:
640-68-6

[ Name ]:
H-D-Val-OH

[Synonym ]:
(R)-(-)-2-Amino-3-methylbutyric acid
D-2-Aminoisovaleric acid
EINECS 211-368-9
D-2-AMINO-3-METHYLBUTANOIC ACID
(2R)-2-amino-3-methylbutanoic acid
(R)-α-Aminoisovaleric acid
(R)-2-Amino-3-methylbutyric acid
d-val
H-D-Val-OH
D-Valine
Valine, D-
MFCD00064219
(R)-(-)-VALINE
(R)-valine
(R)-2-Amino-3-methylbutanoic acid

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
213.6±23.0 °C at 760 mmHg

[ Melting Point ]:
>295 °C (subl.)(lit.)

[ Molecular Formula ]:
C5H11NO2

[ Molecular Weight ]:
117.146

[ Flash Point ]:
83.0±22.6 °C

[ Exact Mass ]:
117.078979

[ PSA ]:
63.32000

[ LogP ]:
0.20

[ Vapour Pressure ]:
0.1±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.461

[ Water Solubility ]:
56 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YV9360000
CHEMICAL NAME :
Valine, D-
CAS REGISTRY NUMBER :
640-68-6
LAST UPDATED :
199706
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C5-H11-N-O2
MOLECULAR WEIGHT :
117.17
WISWESSER LINE NOTATION :
QVYZY1&1 -D

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6093 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 64,319,1956 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9991 No. of Facilities: 35 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 115 (estimated) No. of Female Employees: 64 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
YV9360000

[ HS Code ]:
29224995

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • α-Ketoisovaleric acid
  • D-alanine
  • DL-Valine
  • (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one
  • (4S)-3-((2S)-2-bromo-3-methylbutanoyl)-4-benzyl-1,3-oxazolidin-2-one
  • tert-Butyl 2-amino-3-methylbutanoate
  • Largazole

DownStream

  • (Z)-4-Amino-4-oxobut-2-enoic acid
  • chloroacetyl-dl-valine
  • DL-Valine
  • D(-)-Glutamic acid
  • α-Ketoisovaleric acid
  • (R)-2-ISOPROPYLOXIRANE
  • Carbon dioxide
  • Isobutylamine
  • TERT-BUTYL FORMATE
  • UNII:M69LGV465C

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Salmonella evades D-amino acid oxidase to promote infection in neutrophils.

MBio 5(6) , e01886, (2014)

Neutrophils engulf and kill bacteria using oxidative and nonoxidative mechanisms. Despite robust antimicrobial activity, neutrophils are impaired in directing Salmonella clearance and harbor viable in...

Vitamin D reverses aPL-induced inflammation and LMWH-induced sFlt-1 release by human trophoblast.

Am. J. Reprod. Immunol. 73(3) , 242-50, (2015)

Women with antiphospholipid syndrome (APS) are at increased risk of recurrent pregnancy loss (RPL) and preeclampsia. Antiphospholipid antibodies (aPL) directly alter trophoblast function. Treatment wi...

Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1).

Bioorg. Med. Chem. 19 , 6409-18, (2011)

The proton-coupled amino acid transporter hPAT1 has recently gained much interest due to its ability to transport small drugs thereby allowing their oral administration. A three-dimensional quantitati...


More Articles

Related Compounds

  • H-D-Val-Leu-Lys-AMC acetate salt
  • H-D-Val-OMe.HCl
  • H-D-Val-Oet.HCl
  • H-D-Val-OtBu*pTsOH
  • H-D-Val-Leu-Lys-pNA · 2 HCl
  • H-D-Val-Leu-Lys-chloromethylketone trifluoroacetate salt
  • (2S)-2-amino-3-phenyl-N-(thiophen-2-ylmethyl)propanamide
  • tert-Butyl 4-((5-chloropyrazin-2-yl)oxy)piperidine-1-carboxylate
  • Tert-butyl 4-(5-chloropyridin-2-yloxy)piperidine-1-carboxylate
  • Tert-Butyl 4-(2,2,2-trifluoroethoxy)-1-piperidinecarboxylate
  • (2S)-N-(thiophen-2-ylmethyl)pyrrolidine-2-carboxamide
  • tert-Butyl 3-[(5-chloropyridin-2-yl)oxy]pyrrolidine-1-carboxylate
  • 4-[[6-(Trifluoromethyl)pyrimidine-4-yl]oxy]piperidine-1-carboxylic acid tert-butyl ester
  • 4-[(6-Methoxy-3-pyridazinyl)oxy]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
  • 1-Boc-4-(6-methylpyridin-2-yloxy)piperidine
  • Tert-butyl 4-[5-(trifluoromethyl)pyridin-2-yl]oxypiperidine-1-carboxylate
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