5-Methoxy-1,3-benzoxazol-2-amine

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Names

[ CAS No. ]:
64037-14-5

[ Name ]:
5-Methoxy-1,3-benzoxazol-2-amine

[Synonym ]:
2-Benzoxazolamine, 5-methoxy-
BENZOXAZOLE,2-AMINO-5-METHOXY
2-Benzoxazolamine,5-methoxy
5-methoxy-benzooxazol-2-ylamine
2-Amino-5-methoxybenzoxazole
2-Amino-4-methoxy-benzoxazole
HMS3093P03
5-Methoxy-1,3-benzoxazol-2-amine

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
320.2±34.0 °C at 760 mmHg

[ Molecular Formula ]:
C8H8N2O2

[ Molecular Weight ]:
164.161

[ Flash Point ]:
147.5±25.7 °C

[ Exact Mass ]:
164.058578

[ PSA ]:
61.28000

[ LogP ]:
1.78

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.641

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DM4640000
CHEMICAL NAME :
Benzoxazole, 2-amino-5-methoxy-
CAS REGISTRY NUMBER :
64037-14-5
LAST UPDATED :
199712
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C8-H8-N2-O2
MOLECULAR WEIGHT :
164.18
WISWESSER LINE NOTATION :
T56 BN DOJ CZ HO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDCHAG Medicinal Chemistry: A Series of Monographs. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1963- Volume(issue)/page/year: 4(1),338,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
268 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDCHAG Medicinal Chemistry: A Series of Monographs. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1963- Volume(issue)/page/year: 4(1),338,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1090 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDCHAG Medicinal Chemistry: A Series of Monographs. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1963- Volume(issue)/page/year: 4(1),336,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
432 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDCHAG Medicinal Chemistry: A Series of Monographs. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1963- Volume(issue)/page/year: 4(1),336,1964

Safety Information

[ Hazard Codes ]:
Xn

[ HS Code ]:
2934999090

Synthetic Route

Precursor & DownStream

Precursor

  • 2-Amino-4-methoxyphenol
  • Cyanogen bromide

DownStream

  • 5-Methoxybenzo[d]oxazol-2(3H)-one

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%


Related Compounds

  • (5-methoxy-1,3-benzoxazol-2-yl)methanamine
  • 6-Methoxy-1,3-benzoxazol-2-amine
  • 5-CHLORO-6-METHOXYBENZO[D]OXAZOL-2-AMINE
  • 3-(5-Methoxy-1,3-benzoxazol-2-yl)aniline
  • 5-(5-Methoxy-1,3-benzoxazol-2-yl)-2-methylaniline
  • [1-(5-methoxy-1,3-benzoxazol-2-yl)piperidin-3-yl]acetic acid
  • 3-(2-{[(Tert-butoxy)carbonyl]amino}-5-fluorophenyl)-2-hydroxypropanoic acid
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 1-tert-Butyl 4-ethyl 4-[(2-bromophenyl)methyl]piperidine-1,4-dicarboxylate
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine