Nilotinib (AMN-107)

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Names

[ CAS No. ]:
641571-10-0

[ Name ]:
Nilotinib (AMN-107)

[Synonym ]:
Nilotinib
Nilotinib (AMN-107)
4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-{[4-(3-pyridinyl)-2-pyrimidinyl]amino}benzamide
its intermediates
tasigna
Nilotinib,AMN107,Tasigna
AMN 107
4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluormethyl)phenyl]-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzolcarboxamid
4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzamide
Benzamide, 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-
4-Methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)benzamide
Nilotinib for research
Nilotinib(AMN 107)
4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C28H22F3N7O

[ Molecular Weight ]:
529.516

[ Exact Mass ]:
529.183777

[ PSA ]:
97.62000

[ LogP ]:
5.15

[ Index of Refraction ]:
1.650

[ Storage condition ]:
-20°C Freezer

Safety Information

[ RIDADR ]:
2206

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
  • methyl 4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoate
  • 3-Pyridylboronic acid
  • 3-(diaminomethylideneamino)-4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamide
  • 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
  • N-(3-(TRIFLUOROMETHYL)-5-(4-METHYL-1H-IMIDAZOL-1-YL)PHENYL)-3-IODO-4-METHYLBENZAMIDE
  • 4-pyridin-3-ylpyrimidin-2-amine
  • 4-Methylimidazole
  • N-(3-bromo-5-(trifluoromethyl)phenyl)-4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide

DownStream

  • Nilotinib monohydrochloride monohydrate

Related Compounds

  • Nilotinib-d3
  • Nilotinib Impurity 2
  • nilotinib benzenesulfonate
  • Nilotinib D6
  • Nilotinib hydrochloride anhydrous
  • Nilotinib monohydrochloride monohydrate
  • 6-(Tert-butylamino)-3-(trifluoromethyl)pyridine-2-carboxylic acid
  • 6-[(2-Methylpropyl)amino]-3-(trifluoromethyl)pyridine-2-carboxylic acid
  • 3-[(2-Methylbutan-2-yl)amino]cyclobutane-1-carboxylic acid
  • 2-(Cyclopropylamino)-5-(trifluoromethyl)pyridine-4-carboxylic acid
  • 3-(2-Bromoethyl)-2-chloro-1-benzofuran
  • 2-Amino-2-(4-hydroxy-1,1-dioxo-1lambda6-thiolan-3-yl)acetic acid
  • 3-Amino-3-methylhex-4-enoic acid
  • 2-(1-Aminocyclopent-2-en-1-yl)acetic acid
  • 2-Amino-4-cyano-4-cyclobutylbutanoic acid
  • 4-{Pyrazolo[1,5-a]pyridin-3-yl}pyrrolidine-3-carboxylic acid
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