Nilotinib (AMN-107)

Suppliers

Names

[ Name ]:
Nilotinib (AMN-107)

[Synonym ]:
Nilotinib
Nilotinib (AMN-107)
4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-{[4-(3-pyridinyl)-2-pyrimidinyl]amino}benzamide
its intermediates
tasigna
Nilotinib,AMN107,Tasigna
AMN 107
4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluormethyl)phenyl]-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzolcarboxamid
4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzamide
Benzamide, 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-
4-Methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)benzamide
Nilotinib for research
Nilotinib(AMN 107)
4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₂₈H₂₂F₃N₇O

[ Molecular Weight ]:
529.516

[ Exact Mass ]:
529.183777

[ PSA ]:
97.62000

[ LogP ]:
5.15

[ Index of Refraction ]:
1.650

[ Storage condition ]:
-20°C Freezer

Safety Information

[ RIDADR ]:
2206

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
methyl 4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoate
3-Pyridylboronic acid
3-(diaminomethylideneamino)-4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamide
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
N-(3-(TRIFLUOROMETHYL)-5-(4-METHYL-1H-IMIDAZOL-1-YL)PHENYL)-3-IODO-4-METHYLBENZAMIDE
4-pyridin-3-ylpyrimidin-2-amine
4-Methylimidazole
N-(3-bromo-5-(trifluoromethyl)phenyl)-4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide