Antimycin A
Suppliers
Names
[ CAS No. ]:
642-15-9
[ Name ]:
Antimycin A
[Synonym ]:
dihydrosamidin
Antimycin A1
(2R,3S,6S,7R,8R)-3-[(3-Formamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl 3-methylbutanoate
Isovaleric Acid 8-Ester with 3-Formamide-N-(7-hexyl-8-hydroxy-4,9-dimethyl-2,6-dioxo-1,5-dioxonan-3-yl)salicylamide
Antimycin A
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
757.9±60.0 °C at 760 mmHg
[ Melting Point ]:
139-140ºC
[ Molecular Formula ]:
C28H40N2O9
[ Molecular Weight ]:
548.625
[ Flash Point ]:
412.1±32.9 °C
[ Exact Mass ]:
548.273376
[ PSA ]:
157.33000
[ LogP ]:
4.68
[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C
[ Index of Refraction ]:
1.545
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NY1503500
- CHEMICAL NAME :
- Isovaleric acid, 8-ester with 3-formamido-N-(7-hexyl-8-hydroxy-4,9-dimethyl-2,6-dio xo-1,5- dioxonan-3-yl)salicylamide
- CAS REGISTRY NUMBER :
- 642-15-9
- LAST UPDATED :
- 199309
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C28-H40-N2-O9
- MOLECULAR WEIGHT :
- 548.70
- WISWESSER LINE NOTATION :
- T B666 COV KO&&TJ L1 L1 MOV1Y1&1 NOV1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1469 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JDGRAX Journal of Drug Research. (National Organization for Drug Research and Control, POB 29, Cairo, Egypt) V.2- 1969- Volume(issue)/page/year: 7(2),1,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 7600 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,144,1967
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,144,1967
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 900 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,144,1967
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JDGRAX Journal of Drug Research. (National Organization for Drug Research and Control, POB 29, Cairo, Egypt) V.2- 1969- Volume(issue)/page/year: 7(2),1,1975
Safety Information
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
23/24/25
[ RIDADR ]:
UN 3172
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1(a)