plaunotol

Names

[ Name ]:
plaunotol

[Synonym ]:
18-hydroxygeranylgeraniol
(E,Z,E)-7-Hydroxymethyl-3,11,15-trimethyl-2,6,10,14-hexadecatetraen-1-ol
Plaunotolum [Latin]
CS-684
Plaunotolum
(2Z,6E)-2-((3E)-4,8-Dimethyl-3,7-nonadienyl)-6-methyl-2,6-octadiene-1,8-diol
Kelnac
(2Z,6E)-2-[(3E)-4,8-dimethylnona-3,7-dienyl]-6-methylocta-2,6-diene-1,8-diol

Chemical & Physical Properties

[ Density]:
0.936g/cm3

[ Boiling Point ]:
440.4ºC at 760 mmHg

[ Molecular Formula ]:
C₂₀H₃₄O₂

[ Molecular Weight ]:
306.48

[ Flash Point ]:
190.6ºC

[ Exact Mass ]:
306.25600

[ PSA ]:
40.46000

[ LogP ]:
5.09680

[ Index of Refraction ]:
1.506

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MM0330000

CHEMICAL NAME :: 2,6,10,14-Hexadecatetraen-1-ol, 7-(hydroxymethyl)-3,11,15-trimethyl-, (E,Z,E)-

CAS REGISTRY NUMBER :: 64218-02-6

LAST UPDATED :: 199603

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C20-H34-O2

MOLECULAR WEIGHT :: 306.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10900 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression Gastrointestinal - hypermotility, diarrhea

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 24,599,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SKKNAJ Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku, Tokyo 140, Japan) No.15- 1963- Volume(issue)/page/year: 37,1,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 29500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SKKNAJ Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku, Tokyo 140, Japan) No.15- 1963- Volume(issue)/page/year: 37,1,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8100 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression Gastrointestinal - hypermotility, diarrhea

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 24,599,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 903 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 38,381,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 33725 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 38,381,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 83 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SKKNAJ Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku, Tokyo 140, Japan) No.15- 1963- Volume(issue)/page/year: 37,1,1985 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10500 uL/kg/5W-I

TOXIC EFFECTS :: Liver - fatty liver degeneration Liver - changes in liver weight

REFERENCE :: YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 38,381,1987

Safety Information

[ HS Code ]:
2905399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(2E,6Z,10E)-3,11,15-trimethyl-7-(triisopropylsiloxymethyl)hexadeca-2,6,10,14-tetraen-1-ol
(E,Z,E)-1-tert-Butyldimethylsilyloxy-7-hydroxymethyl-3,11,15-trimethylhexadecatetra-2,6,10,14-ene
(3E)-4,8-Dimethyl-1,3,7-nonatriene
(E)-2-bromo-6-methylocta-2,6-diene-1,8-diol
(2E,6Z,10E)-1-benzyloxy-7-[(benzyloxy)methyl]-3,11,15-trimethyl-9-phenylthio-2,6,10,14-hexadecatetraene
(2Z,5E)-6,10-dimethyl-2-((E)-4-methyl-6-((tetrahydro-2H-pyran-2-yl)oxy)hex-4-en-1-ylidene)undeca-5,9-dien-1-ol
(2Z,5E)-2-((E)-6-(benzyloxy)-4-methylhex-4-en-1-ylidene)-6,10-dimethylundeca-5,9-dien-1-ol
3,7-dimethylocta-2,6-dienoxymethylbenzene
(E)-1-((3,7-dimethylocta-2,6-dien-1-yl)sulfonyl)-4-methylbenzene

DownStream

Customs

[ HS Code ]: 2905399090

[ Summary ]:
2905399090 other diols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%