atracurium besylate

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Names

[ Name ]:
atracurium besylate

[Synonym ]:
NIMBEX
bisbenzènesulfonate de 2,2'-{pentane-1,5-diylbis[oxy(3-oxopropane-3,1-diyl)]}bis[1-(3,4-diméthoxybenzyl)-6,7-diméthoxy-2-méthyl-1,2,3,4-tétrahydroisoquinoléinium]
2,2'-{1,5-Pentanediylbis[oxy(3-oxo-3,1-propanediyl)]}bis[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium] bisbenzenesulfonate
MFCD00797403
2,2'-{Pentan-1,5-diylbis[oxy(3-oxopropan-3,1-diyl)]}bis[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisochinolinium]bisbenzolsulfonat
2,2'-{Pentane-1,5-diylbis[oxy(3-oxopropane-3,1-diyl)]}bis[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium] bisbenzenesulfonate
atracurium besylate
atracurium besilate [INN_en]
2,2'-{pentane-1,5-diylbis[oxy(3-oxopropane-3,1-diyl)]}bis[1-{[3,4-bis(methyloxy)phenyl]methyl}-2-methyl-6,7-bis(methyloxy)-1,2,3,4-tetrahydroisoquinolinium] bisbenzenesulfonate
EINECS 264-743-4
Atracurium Besylate Cisatracurium
Isoquinolinium, 2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl- benzenesulfonate (1:2)

Chemical & Physical Properties

[ Melting Point ]:
85-90ºC

[ Molecular Formula ]:
C₆₅H₈₂N₂O₁₈S₂

[ Molecular Weight ]:
1243.479

[ Exact Mass ]:
1242.500366

[ PSA ]:
257.60000

[ LogP ]:
11.32610

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: ~27 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Atracurium oxalate
Methyl benzenesulfonate
3,4-Dimethoxyphenylacetic acid
N-(3,4-Dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)acetamide
1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxyisoquinoline
3,4-Dimethoxyphenethylamine
Tetrahydropapaverine hydrochloride

DownStream

Articles

How Does High-Concentration Supplemental Perioperative Oxygen Influence Surgical Outcomes after Thyroid Surgery? A Prospective, Randomized, Double-Blind, Controlled, Monocentric Trial

J. Am. Coll. Surg. 220(5) , 921-33, (2015)

Background Recurrent laryngeal nerve palsy (RLNP) and hypoparathyroidism are complications of thyroid surgery. The convalescence can depend on several factors (ie, pain, fatigue, nausea, and vomiting)...

Intravenous lidocaine decreases tumor necrosis factor alpha expression both locally and systemically in pigs undergoing lung resection surgery.

Anesth. Analg. 119(4) , 815-28, (2014)

Lung resection surgery is associated with an inflammatory reaction. The use of 1-lung ventilation (OLV) seems to increase the likelihood of this reaction. Different prophylactic and therapeutic measur...

Dexmedetomidine reduces propofol and remifentanil requirements during bispectral index-guided closed-loop anesthesia: a double-blind, placebo-controlled trial.

Anesth. Analg. 118(5) , 946-55, (2014)

The α2-adrenergic agonist dexmedetomidine is a sedative and can be used as an adjunct to anesthetics. Our primary goal was thus to determine the extent to which dexmedetomidine reduces the requirement...

Cisatracurium Besylate
Cisatracurium besylate impurity19
Atracurium oxalate
atracurium
Epelsiban besylate
Mirogabalin besylate
Tert-butyl 3-(aminomethyl)oxolane-3-carboxylate
3-(Methoxycarbonyl)oxetane-3-carboxylic acid
3-Methoxyazetidine-1-carbonyl chloride
4,4,4-Trifluoro-3-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]butanoic acid
2-{bicyclo[2.2.1]heptan-2-yl}-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetic acid
tert-Butyl 1-(chlorosulfonyl)piperidine-2-carboxylate
(3S,4R)-4-Methoxytetrahydrofuran-3-sulfonamide
tert-Butyl 3-(1-aminoethyl)-3-hydroxyazetidine-1-carboxylate
8-Thiabicyclo[3.2.1]octan-3-amine
4-Carboxymethyl-3,3-dimethyl-piperidine-1-carboxylic acid benzyl ester

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