Erythromycin stearate
Suppliers
Names
[ CAS No. ]:
643-22-1
[ Name ]:
Erythromycin stearate
[Synonym ]:
EINECS 211-396-1
MFCD00084690
Heptadecanoic acid - (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione (1:1)
Erythromycin stearate
Chemical & Physical Properties
[ Density]:
1.112g/cm3
[ Melting Point ]:
77-79ºC
[ Molecular Formula ]:
C55H103NO15
[ Molecular Weight ]:
1004.377
[ Flash Point ]:
523.101ºC
[ Exact Mass ]:
1003.717102
[ PSA ]:
231.21000
[ LogP ]:
8.11810
[ Index of Refraction ]:
1.518
[ Storage condition ]:
2-8°C
[ Stability ]:
Stable. Combustible. Incompatible with acids, strong oxidizing agents.
[ Water Solubility ]:
ethanol: soluble50mg/mL, clear to very slightly hazy, colorless
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KF5785000
- CHEMICAL NAME :
- Erythromycin, stearate (salt)
- CAS REGISTRY NUMBER :
- 643-22-1
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C37-H67-N-O13.C18-H36-O2
- MOLECULAR WEIGHT :
- 1018.59
- WISWESSER LINE NOTATION :
- T-14-VO GVTJ C2 DQ D EQ F H JQ J L N KO- BT6OTJ CQ DN1&1 F& MO- FT6OTJ B CQ DO1 D &622
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - changes in structure or function of endocrine pancreas Gastrointestinal - nausea or vomiting Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
- REFERENCE :
- JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 34,93,1996
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3112 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,211,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >2500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,211,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 413 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,211,1990 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 13037 mg/kg/14D-C
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Gastrointestinal - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-338,1988
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 71 gm/kg/14D-C
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Gastrointestinal - other changes Related to Chronic Data - death
- REFERENCE :
- NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-338,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0726 No. of Facilities: 592 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 1977 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0726 No. of Facilities: 78 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1108 (estimated) No. of Female Employees: 615 (estimated)
Safety Information
[ Symbol ]:
GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H317-H334
[ Precautionary Statements ]:
P261-P280-P284-P304 + P340-P342 + P311
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R42/43
[ Safety Phrases ]:
S36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
2
[ RTECS ]:
KF5785000
[ HS Code ]:
2942000000
Customs
[ HS Code ]: 2942000000
Articles
Cochrane Database Syst. Rev. (9) , CD003767, (2011)
Preterm birth is a significant perinatal problem contributing to perinatal morbidity and mortality. Heavy vaginal ureaplasma colonisation is suspected of playing a role in preterm birth and preterm ru...
Wien. Klin. Wochenschr. 111(2) , 76-7, (1999)
Erythromycin is a frequently used antibiotic in patients with atypical respiratory infection and/or an allergy to penicillin. We report the case of a young woman who developed severe cholestasis and j...
Scand. J. Infect. Dis. 24(2) , 219-25, (1992)
The efficacy and tolerance of roxithromycin 150 mg b.i.d. were compared with those of erythromycin stearate 500 mg b.i.d. in patients with lower respiratory tract infections. Out of 86 patients recrui...