6,7-Dimethoxy-2,2-dimethylchromene

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Names

[ CAS No. ]:
644-06-4

[ Name ]:
6,7-Dimethoxy-2,2-dimethylchromene

[Synonym ]:
2H-1-BENZOPYRAN,6,7-DIMETHOXY-2,2-DIMETHYL
6,7-dimethoxy-2,2-dimethyl-3-chromene
EINECS 211-408-5
6,7-Dimethoxy-2,2-dimethyl-2H-1-benzopyran
precocenes II
2H-1-Benzopyran, 6,7-dimethoxy-2,2-dimethyl-
6,7-Dimethoxy-2,2-dimethyl2H-1-benzopyran
6,7-Dimethoxy-2,2-dimethyl-2H-benzopyran
6,7-Dimethoxy-2,2-dimethylchromene
6,7-Dimethoxy-2,2-dimethyl-2H-chromene
PRICOCENE II
Ageratochromene
Precocen 2
6,7-dimethoxy-2,2-dimethylchrom-3-ene
Precocene 2

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
300.4±42.0 °C at 760 mmHg

[ Melting Point ]:
47.5ºC

[ Molecular Formula ]:
C13H16O3

[ Molecular Weight ]:
220.26

[ Flash Point ]:
100.0±25.2 °C

[ Exact Mass ]:
220.109940

[ PSA ]:
27.69000

[ LogP ]:
3.38

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.514

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DJ2527000
CHEMICAL NAME :
2H-1-Benzopyran, 6,7-dimethoxy-2,2-dimethyl-
CAS REGISTRY NUMBER :
644-06-4
BEILSTEIN REFERENCE NO. :
0160683
LAST UPDATED :
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C13-H16-O3
MOLECULAR WEIGHT :
220.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg/5D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes primarily in glomeruli Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - hematuria
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
27536 ug/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
Specific locus test

MUTATION DATA

TYPE OF TEST :
Unscheduled DNA synthesis
TEST SYSTEM :
Rodent - rat Liver
DOSE/DURATION :
1 umol/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 26,311,1985

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S24/25

[ RTECS ]:
DJ2527000

[ HS Code ]:
2909199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3,4-Dimethoxyphenol
  • 3-Methyl-2-butenal
  • N-(7-amino-8-(4-chlorobenzyl)-2,2-dimethyl-5-oxo-2,3,5,8-tetrahydroimidazo[1,2-a]pyrimidin-6-yl)formamide
  • 1,2-dimethoxy-4-(2-methylbut-3-yn-2-yloxy)benzene
  • 7-methoxy-2,2-dimethyl-2H-1-Benzopyran-6-ol
  • methyl iodide
  • 6,7-dimethoxy-2,2-dimethyl-3,4-dihydrochromen-4-ol
  • 4-Chromanone
  • 6,7-dimethoxy-2,2-dimethyl-3H-chromen-4-one
  • 3,4-dihydro-6,7-dimethoxy-2,2-dimethyl-2H-1-Benzopyran

DownStream

  • 6,7-dimethoxy-2,2-dimethyl-3-nitrochromene
  • 5,6-dimethoxy-2,2-dimethyl-1a,7b-dihydrooxireno[2,3-c]chromene

Customs

[ HS Code ]: 2909199090

[ Summary ]:
2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Related Compounds

  • 3,4-dichloro-6,7-dimethoxy-2,2-dimethylchromene
  • 6,7-dimethoxy-2,2-dimethyl-3,4-dihydrochromen-3-ol
  • 6,7-dimethoxy-2-(2-(4-methoxyphenyl)ethyl)chromone
  • 6,7-dimethoxy-2-[2-(3,4,5,6-tetrahydro-2H-pyridin-1-yl)ethyl]-3,4-dihy dro-1H-isoquinoline dichloride
  • 6,7-dimethoxy-2,2-dimethyl-3-nitrochromene
  • 6,7-dimethoxy-2,2-dimethyl-3,4-dihydrochromen-4-ol
  • 1-(2-Chloro-4-hydroxyphenyl)-2-(methylamino)ethan-1-one
  • 3-Amino-1-(2-chloro-4-hydroxyphenyl)propan-1-one
  • 2-Amino-1-(2-chloro-4-hydroxyphenyl)propan-1-one
  • 4,4,6-Trimethyl-1,2,3,4-tetrahydronaphthalen-1-amine
  • 1-(1H-imidazol-2-yl)-2-methylpropan-1-ol
  • 2-Amino-1-(4-chloro-2-hydroxyphenyl)propan-1-one
  • 2,2,2-Trifluoro-N-[4-(trifluoromethyl)phenyl]acetimidoyl Chloride
  • 2-Amino-3-(3-bromopyridin-4-yl)propanoic acid
  • 2-Amino-1-(3-chloro-2-methoxyphenyl)ethan-1-one
  • 1-(3-Chloro-2-hydroxyphenyl)-2-(methylamino)ethan-1-one
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