1,2,3-Trimethoxy-5-methylbenzene

Names

[ Name ]:
1,2,3-Trimethoxy-5-methylbenzene

[Synonym ]:
3,4,5-Trimethoxytoluene
EINECS 229-239-0
1,2,3-Trimethoxy-5-methylbenzene
Benzene, 1,2,3-trimethoxy-5-methyl-
MFCD00008397

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
272.0±0.0 °C at 760 mmHg

[ Melting Point ]:
24-26 °C(lit.)

[ Molecular Formula ]:
C₁₀H₁₄O₃

[ Molecular Weight ]:
182.216

[ Flash Point ]:
74.4±0.0 °C

[ Exact Mass ]:
182.094299

[ PSA ]:
27.69000

[ LogP ]:
2.12

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.487

MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S23-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

3,4,5-Trimethoxybenzaldehyde
(3,4,5-Trimethoxyphenyl)methanol
Methanol
n-butylamine
1-(2-hexyl)-2,5-dimethylbenzene
p-Toluenesulfonic acid
Methylboronic acid
2,6-Dibromo-4-methylanisole

DownStream

1,2,3-trimethoxy-5-[2-(3-methoxyphenyl)ethyl]benzene
2,3-Dimethoxy-5-methyl-1,4-benzenediol
Ubiquinone Q0
2,3,4-Trimethoxy-6-methylphenol
2,3,4,5-Tetramethoxytoluene
1,3-Dimethoxy-5-methylbenzene
2-hydroxy-3,4-dimethoxy-6-methylbenzaldehyde
metrafenone (prov)
acetic acid 3,4,5-trimethoxybenzyl ester
3,4,5-Trimethoxybenzaldehyde

Articles

Aqueous chlorination of the antibacterial agent trimethoprim: reaction kinetics and pathways.

Water Res. 41(3) , 647-55, (2007)

Trimethoprim (TMP), one of the antibacterials most frequently detected in municipal wastewaters and surface waters, reacts readily with free available chlorine (i.e., HOCl) at pH values between 3 and ...

Synthesis and biological evaluation of phenanthrenes as cytotoxic agents with pharmacophore modeling and ChemGPS-NP prediction as topo II inhibitors.

PLoS ONE 7 , e37897, (2012)

In a structure-activity relationship (SAR) study, 3-methoxy-1,4-phenanthrenequinones, calanquinone A (6a), denbinobin (6b), 5-OAc-calanquinone A (7a) and 5-OAc-denbinobin (7b), have significantly prom...

Constituents of Asarum sieboldii with inhibitory activity on lipopolysaccharide (LPS)-induced NO production in BV-2 microglial cells.

Chem. Biodivers. 5(2) , 346-51, (2008)

Bioassay-guided fractionation of the root extract of Asarum sieboldii led to the isolation of the four active compounds (-)-sesamin (1), (2E,4E,8Z,10E)-N-(2-methylpropyl)dodeca-2,4,8,10-tetraenamide (...

1,2,3-trimethoxy-5-[2-(4-methoxyphenyl)ethynyl]benzene
1,2,3-trimethoxy-5-[(Z)-2-phenylethenyl]benzene
1,2,3-trimethoxy-5-styrylbenzene
1,2,3-trimethoxy-5-(2-nitro-propenyl)benzene
1,2,3-trimethoxy-5-(2-nitroethyl)benzene
1,2,3-trimethoxy-5-[(1E,3E)-4-(3,4,5-trimethoxyphenyl)buta-1,3-dienyl]benzene
(1,3,5-Trimethylpyrazol-4-yl) 3,6-dichloropyridine-2-carboxylate
7-(4-Methylpiperazin-1-yl)thiazolo[4,5-d]pyrimidin-5-amine
(2-Chloropyridin-4-yl)-(2-methyl-1,2,3,4-tetrahydro-1,5-benzodiazepin-5-yl)methanone
2-Chloro-N-(4-cyanophenyl)-N-(2-methoxyethyl)pyridine-4-carboxamide
3-Amino-2-(3-fluorophenyl)quinazolin-4(3H)-one
3-Amino-2-(4-(trifluoromethyl)phenyl)quinazolin-4(3H)-one
2-(3,5-Dimethylfuran-2-yl)acetic acid
3-Amino-2-(benzo[D][1,3]dioxol-5-YL)quinazolin-4(3H)-one
3-Amino-2-(2-fluorophenyl)pyrido[2,3-D]pyrimidin-4(3H)-one
6-Fluoro-4-methyl-2,3-dihydro-1,4-benzoxazine

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