Scoulerine

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Names

[ Name ]:
Scoulerine

[Synonym ]:
2,9-DIOXY-3,10-DIMETHOXYBERBINE
(±)-Scoulerine
3,10-Dimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline-2,9-diol
6H-Dibenzo(a,g)quinolizine-2,9-diol, 5,8,13,13a-tetrahydro-3,10-dimethoxy-
6H-Dibenzo[a,g]quinolizine-2,9-diol, 5,8,13,13a-tetrahydro-3,10-dimethoxy-
Scoulerin
Aequaline
Alkaloid HF-1
l-scoulerine
(RS)-Scoulerine
scoulerine
l-skoulerine

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
503.3±50.0 °C at 760 mmHg

[ Melting Point ]:
192ºC

[ Molecular Formula ]:
C₁₉H₂₁NO₄

[ Molecular Weight ]:
327.374

[ Flash Point ]:
258.2±30.1 °C

[ Exact Mass ]:
327.147064

[ PSA ]:
62.16000

[ LogP ]:
2.16

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.680

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DR9808600

CHEMICAL NAME :: 13a-alpha-Berbine-2,9-diol, 3,10-dimethoxy-

CAS REGISTRY NUMBER :: 6451-73-6

LAST UPDATED :: 199012

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H21-N-O4

MOLECULAR WEIGHT :: 327.41

WISWESSER LINE NOTATION :: T D6 B666 KN&TT&J GO1 HQ PO1 QQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,26,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 275 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: MZUZA8 Meditsinskii Zhurnal Uzbekistana. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1957- Volume(issue)/page/year: (6),39,1977

Safety Information

[ Hazard Codes ]:
Xi