amitriptyline metabolite (+/-)-

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Names

[ Name ]:
amitriptyline metabolite (+/-)-

[Synonym ]:
5H-Dibenzo(a,d)cyclohepten-10-ol,5-(3-(dimethylamino)propylidene)-10,11-dihydro-,(E)
( inverted exclamation markA)-(E)-5-[3-(Dimethylamino)propylidene]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol
Amitriptyline metabolite,( inverted exclamation markA)-E-10-hydroxylated

Chemical & Physical Properties

[ Density]:
1.151g/cm3

[ Boiling Point ]:
453.3ºC at 760mmHg

[ Melting Point ]:
97-99 °C

[ Molecular Formula ]:
C₂₀H₂₃NO

[ Molecular Weight ]:
293.40300

[ Flash Point ]:
225.4ºC

[ Exact Mass ]:
293.17800

[ PSA ]:
23.47000

[ LogP ]:
3.65950

[ Appearance of Characters ]:
solid | white

[ Index of Refraction ]:
1.651

[ Water Solubility ]:
0.1 M HCl: soluble

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes.

Clin. Pharmacol. Ther. 52(4) , 350-8, (1992)

In 26 hospitalized patients with depression, a combined pharmacogenetic test with dextromethorphan, a substrate of cytochrome P450IID6, and mephenytoin, the S-form of which is hydroxylated by a P450II...

Demethylation and hydroxylation of amitriptyline, nortriptyline, and 10-hydroxyamitriptyline in human liver microsomes.

Drug Metab. Dispos. 9(6) , 565-8, (1981)

The rates of demethylation and hydroxylation of amitriptyline, nortriptyline, and 10-hydroxyamitriptyline by microsomes from adult human livers were determined by use of mass-fragmentographic or liqui...

CYP2D6 and CYP2C19 genotypes and amitriptyline metabolite ratios in a series of medicolegal autopsies.

Forensic Sci. Int. 158(2-3) , 177-83, (2006)

In a series of 202 postmortem toxicology cases, the CYP2D6 and CYP2C19 genes were genotyped, and the concentrations of amitriptyline (AT) and six metabolites were analyzed. The polymorphic CYP2D6 and ...