1,3-Dioxolane

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Names

[ CAS No. ]:
646-06-0

[ Name ]:
1,3-Dioxolane

[Synonym ]:
1.3-dioxolane
1,4-dioxolane
1,3-Dioxolan
1,3-dioxalane
Formal glycol
MFCD00003207
ethylene glycol methylene ether
trans dioxolane
ethylene glycol formal
EINECS 211-463-5
cis dioxolane
dioxolane, 1,3-
1,3-dioxacyclopentane
Glycol formal
1,3-Dioxolane

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
75.6±0.0 °C at 760 mmHg

[ Melting Point ]:
−95 °C(lit.)

[ Molecular Formula ]:
C₃H₆O₂

[ Molecular Weight ]:
74.078

[ Flash Point ]:
1.7±0.0 °C

[ Exact Mass ]:
74.036781

[ PSA ]:
18.46000

[ LogP ]:
-0.73

[ Vapour density ]:
2.6 (vs air)

[ Vapour Pressure ]:
114.6±0.1 mmHg at 25°C

[ Index of Refraction ]:
1.397

[ Stability ]:
Below 4°C

[ Water Solubility ]:
SOLUBLE

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JH6760000

CHEMICAL NAME :: 1,3-Dioxolane

CAS REGISTRY NUMBER :: 646-06-0

LAST UPDATED :: 199806

DATA ITEMS CITED :: 20

MOLECULAR FORMULA :: C3-H6-O2

MOLECULAR WEIGHT :: 74.09

WISWESSER LINE NOTATION :: T5O COTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20650 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - renal function tests depressed

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10500 mg/m3/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 32000 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 8480 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1360 mg/m3/4H/22W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - urine volume increased Blood - other changes

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3000 ppm/6H/13W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Endocrine - changes in spleen weight Blood - changes in leukocyte (WBC) count

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1360 mg/m3/4H/22W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - urine volume increased Blood - other changes

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 105000 mg/m3/50D-I

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 290 mg/kg

REFERENCE :: STBIBN Studia Biophysica. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086, Ger. Dem. Rep.) V.1- 1966- Volume(issue)/page/year: 107,205,1985 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-HUNGARY:TWA 10 mg/m3;STEL 20 mg/m3;Skin;Carcinogen JAN 1993 OEL-RUSSIA:STEL 50 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84001 No. of Facilities: 256 (estimated) No. of Industries: 13 No. of Occupations: 23 No. of Employees: 10612 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84001 No. of Facilities: 5264 (estimated) No. of Industries: 86 No. of Occupations: 44 No. of Employees: 74949 (estimated) No. of Female Employees: 747 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H319

[ Precautionary Statements ]:
P210-P305 + P351 + P338-P370 + P378-P403 + P235

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)

[ Hazard Codes ]:
F:Flammable;

[ Risk Phrases ]:
R11

[ Safety Phrases ]:
S16

[ RIDADR ]:
UN 1166 3/PG 2

[ WGK Germany ]:
1

[ RTECS ]:
JH6760000

[ Packaging Group ]:
II

[ Hazard Class ]:
3

[ HS Code ]:
29329970

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

carbon monoxide
ch3cho
2-Ethoxy-1,3-dioxolane
Ethylene glycol
Formaldehyde
(CH2CH2O2)B(O-n-C4H9)
2-(3-methyl-butoxy)-[1,3,2]dioxaborolane
ETHYLENE OXIDE

DownStream

2-METHOXY-1,3-DIOXOLANE
4-methoxy-1,3-dioxolane
Trimethyl orthoformate
Methyl 6-methylnicotinate
Methyl 4,6-dimethylnicotinate
BIS(CHLOROMETHYL) ETHER
2-Chloroethyl Chloromethyl Ether
Bis(chloroethyl) ether
Chloromethane
2-chloroethyl formate

Customs

[ HS Code ]: 29329970

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