AS-605240

Suppliers

Names

[ Name ]:
AS-605240

[Synonym ]:
PI 3-Kinase Inhibitor
AS605240
2,4-Thiazolidinedione, 5-(6-quinoxalinylmethylene)-, (5Z)-
(5Z)-5-(Quinoxalin-6-ylmethylene)-1,3-thiazolidine-2,4-dione
(5Z)-5-(6-Quinoxalinylmethylene)-1,3-thiazolidine-2,4-dione
5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione
AS 605240
AS-605240

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C₁₂H₇N₃O₂S

[ Molecular Weight ]:
257.268

[ Exact Mass ]:
257.025909

[ PSA ]:
97.25000

[ LogP ]:
0.52

[ Appearance of Characters ]:
, faint red to orange to dark brown

[ Index of Refraction ]:
1.792

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: soluble1mg/mL, clear (warmed)

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

Articles

PI3K inhibition synergizes with glucocorticoids but antagonizes with methotrexate in T-cell acute lymphoblastic leukemia.

Oncotarget 6 , 13105-18, (2015)

The PI3K pathway is frequently hyperactivated in primary T-cell acute lymphoblastic leukemia (T-ALL) cells. Activation of the PI3K pathway has been suggested as one mechanism of glucocorticoid resista...

Short-term hypoxia enhances the migratory capability of dendritic cell through HIF-1α and PI3K/Akt pathway.

J. Cell Physiol. 229(12) , 2067-76, (2014)

Hypoxia represents an inadequate oxygen supply to tissues, which can modulate cell functions, primarily through the hypoxia-inducible transcription factor HIF-1α. Dendritic cells (DC) are professional...

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