Phomopsin A

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Names

[ CAS No. ]:
64925-80-0

[ Name ]:
Phomopsin A

[Synonym ]:
phomopsin a from phomopsis leptostromiformis
phomopsin
PMSA

Chemical & Physical Properties

[ Density]:
1.48g/cm3

[ Boiling Point ]:
1188.2ºC at 760 mmHg

[ Molecular Formula ]:
C36H45ClN6O12

[ Molecular Weight ]:
789.22800

[ Flash Point ]:
672.4ºC

[ Exact Mass ]:
788.27800

[ PSA ]:
273.03000

[ LogP ]:
2.27850

[ Index of Refraction ]:
1.655

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SY2593000
CHEMICAL NAME :
Phomopsin A
CAS REGISTRY NUMBER :
64925-80-0
LAST UPDATED :
199801

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - domestic
DOSE/DURATION :
10 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Mammal - domestic
DOSE/DURATION :
1 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Mammal - domestic
DOSE/DURATION :
1 mg/kg/1W-I
TOXIC EFFECTS :
Behavioral - food intake (animal) Liver - other changes Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Mammal - domestic
DOSE/DURATION :
1 mg/kg/4W-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Liver - jaundice (or hyperbilirubinemia) hepatocellular
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
150 ug/kg
SEX/DURATION :
female 6-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
400 ug/kg
SEX/DURATION :
female 6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
10 mg/L
REFERENCE :
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969- Volume(issue)/page/year: 46,79,1986

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
20/21/22-40


Related Compounds

  • actinoplanone A
  • Thapsuine A
  • Apocynol A
  • (2S)-N-[(2S,5S,8S,11R,12S,15S,18S,21R)-5-[(3-bromo-4-methoxyphenyl)methyl]-2-[(2S)-butan-2-yl]-15-[3-(carbamoylamino)propyl]-21-hydroxy-4,11-dimethyl-3,6,9,13,16,22-hexaoxo-8-propan-2-yl-10-oxa-1,4,7,14,17-pentazabicyclo[16.3.1]docosan-12-yl]-2-(butanoyla
  • Pseudoanguillosporin A
  • Digitoside A
  • 3-(5-Bromo-1,3-thiazol-2-yl)-2,2-dimethylcyclopropan-1-amine
  • 2-methoxy-2-(1-methyl-1H-indol-7-yl)propan-1-amine
  • [1-(3-bromo-1-methyl-1H-pyrazol-5-yl)-2,2-dimethylcyclopropyl]methanamine
  • 4-Cyclopropyl-1-[(propan-2-yl)amino]hexane-2,4-diol
  • (1S)-1-[2-(dimethylamino)-5-fluorophenyl]-2,2,2-trifluoroethan-1-ol
  • (1-{[3-(Trifluoromethyl)pyridin-4-yl]methyl}cyclopropyl)methanol
  • 3-(3-Bromo-4-chlorophenyl)-3-methylbutan-1-amine
  • 1-[4-(cyclopropylmethyl)-4H-1,2,4-triazol-3-yl]methanamine
  • tert-butyl N-(2-methyl-6-oxoheptan-3-yl)carbamate
  • 4-[4-(Diethylamino)-2-hydroxyphenyl]butanal
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