Pifithrin-µ
Suppliers
Names
[ CAS No. ]:
64984-31-2
[ Name ]:
Pifithrin-µ
[Synonym ]:
2-Phenylethynesulfonamide
Pifithrin-mu
2-Phenylacetylenesulfonamide
Phenyl-ethynesulfonic acid amide
Ethynesulfonamide, 2-phenyl-
Phenylethynsulfonic acid amide
PFTmu
Pifithrin-μ
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
351.7±25.0 °C at 760 mmHg
[ Melting Point ]:
135.0 to 139.0 °C
[ Molecular Formula ]:
C8H7NO2S
[ Molecular Weight ]:
181.212
[ Flash Point ]:
166.5±23.2 °C
[ Exact Mass ]:
181.019745
[ PSA ]:
68.54000
[ LogP ]:
2.00
[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C
[ Index of Refraction ]:
1.634
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
DMSO: soluble >10mg/mL, clear
MSDS
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
22-36/37/38
[ Safety Phrases ]:
26
[ RIDADR ]:
NONH for all modes of transport
[ HS Code ]:
2935009090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2935009090
[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%
Articles
Cancer Lett. 354(1) , 115-21, (2014)
PES (2-phenylethynesulfonamide) was initially identified as an inhibitor of p53 translocation to mitochondria and named Pifithrin-µ. Further studies showed that PES selectively killed tumour cells and...
EMBO J. 34(4) , 559-77, (2015)
The loading of small interfering RNAs (siRNAs) and microRNAs into Argonaute proteins is enhanced by Hsp90 and ATP in diverse eukaryotes. However, whether this loading also occurs independently of Hsp9...
Cancer. Immunol. Res. 3 , 678-88, (2015)
Immune responses contribute to the success of radiotherapy of solid tumors; however, the mechanism of triggering CD8(+) T-cell responses is poorly understood. Antigen cross-presentation from tumor cel...