Pifithrin-µ

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Names

[ CAS No. ]:
64984-31-2

[ Name ]:
Pifithrin-µ

[Synonym ]:
2-Phenylethynesulfonamide
Pifithrin-mu
2-Phenylacetylenesulfonamide
Phenyl-ethynesulfonic acid amide
Ethynesulfonamide, 2-phenyl-
Phenylethynsulfonic acid amide
PFTmu
Pifithrin-μ

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
351.7±25.0 °C at 760 mmHg

[ Melting Point ]:
135.0 to 139.0 °C

[ Molecular Formula ]:
C8H7NO2S

[ Molecular Weight ]:
181.212

[ Flash Point ]:
166.5±23.2 °C

[ Exact Mass ]:
181.019745

[ PSA ]:
68.54000

[ LogP ]:
2.00

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.634

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: soluble >10mg/mL, clear

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
22-36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2935009090

Synthetic Route

Precursor & DownStream

Precursor

  • (Z)-2-chloro-2-phenyl-ethenesulfonamide
  • α-acetophenonesulfonic acidsodium salt

DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles

Cell death induced by 2-phenylethynesulfonamide uncovers a pro-survival function of BAX.

Cancer Lett. 354(1) , 115-21, (2014)

PES (2-phenylethynesulfonamide) was initially identified as an inhibitor of p53 translocation to mitochondria and named Pifithrin-µ. Further studies showed that PES selectively killed tumour cells and...

A Tetrahymena Hsp90 co-chaperone promotes siRNA loading by ATP-dependent and ATP-independent mechanisms.

EMBO J. 34(4) , 559-77, (2015)

The loading of small interfering RNAs (siRNAs) and microRNAs into Argonaute proteins is enhanced by Hsp90 and ATP in diverse eukaryotes. However, whether this loading also occurs independently of Hsp9...

Cross-Presentation of the Oncofetal Tumor Antigen 5T4 from Irradiated Prostate Cancer Cells--A Key Role for Heat-Shock Protein 70 and Receptor CD91.

Cancer. Immunol. Res. 3 , 678-88, (2015)

Immune responses contribute to the success of radiotherapy of solid tumors; however, the mechanism of triggering CD8(+) T-cell responses is poorly understood. Antigen cross-presentation from tumor cel...


More Articles


Related Compounds

  • Pifithrin-β
  • Pifithrin-β (hydrobromide)
  • Pifithrin-α hydrobromide
  • Pifithrin-α, p-Nitro, Cyclic
  • u-Conotoxin GIIIA
  • Chiralyst P889
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • (5-nitro-1H-indol-3-yl)methanol
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • N-(3-acetylphenyl)-4-[4-(4-fluorophenyl)piperazino]-4-oxobutanamide