Cytidine

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Names

[ CAS No. ]:
65-46-3

[ Name ]:
Cytidine

[Synonym ]:
1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine
EINECS 200-610-9
4-Amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-2(1H)-pyrimidinone
2(1H)-Pyrimidinone, 4-amino-1-β-D-ribofuranosyl-
1-β-D-Ribofuranosylcytosine
4-Amino-1-β-δ-ribofuranosyl-2(1H)-pyrimidinone
4-Amino-1-(β-D-ribofuranosyl)pyrimidin-2(1H)-on
MFCD02181091
Cytidine
4-Amino-1-b-D-ribofuranosyl-2(1H)-pyrimidinone
Cyd
Cytidin
1-β-D-ribofuranosyl-Cytosine
Citidine
1-(b-δ-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine
Cytosine, 1-β-D-ribofuranosyl-
d-cytidine
1-β-δ-Ribofuranosylcytosine
CYTIDINE extrapure
1-b-D-Ribofuranosylcytosine
2-Pyrimidinol, 1,4-dihydro-4-imino-1-β-D-ribofuranosyl-
4-Imino-1-(β-D-ribofuranosyl)-1,4-dihydro-2-pyrimidinol

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
529.7±60.0 °C at 760 mmHg

[ Melting Point ]:
210-220 °C (dec.)(lit.)

[ Molecular Formula ]:
C₉H₁₃N₃O₅

[ Molecular Weight ]:
243.217

[ Flash Point ]:
274.1±32.9 °C

[ Exact Mass ]:
243.085526

[ PSA ]:
130.83000

[ LogP ]:
-1.78

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.756

[ Water Solubility ]:
SOLUBLE

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UW7370000

CHEMICAL NAME :: 2(1H)-Pyrimidinone, 4-amino-1-beta-D-ribofuranosyl-

CAS REGISTRY NUMBER :: 65-46-3

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C9-H13-N3-O5

MOLECULAR WEIGHT :: 243.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2700 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 150 umol/L

REFERENCE :: PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 48,686,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9990 No. of Facilities: 35 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 115 (estimated) No. of Female Employees: 64 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
F+

[ Risk Phrases ]:
R68

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UW7370000

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2',3',5'-TRI-O-ACETYLCYTIDINE
N-Acetyl-2'-O,3'-O,5'-O-triacetylcytidine
N4-(O-(benzyloxy))cytidine
xylocytidine
Cytidine, N-benzoyl-,2',3',5'-tribenzoate (7CI,9CI)
Uridine
Cytidine,2',3'-O-(1-methylethylidene)-

DownStream

5-Bromocytidine
N-Acetylcytidine
Ancitabine
D-Ribose
cytosine
Ribavirin
uridine triacetate
3-Methylcytidine
3'-(O-METHYL)CYTIDINE
2′-O-methylcytidine

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

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Nat. Commun. 6 , 6513, (2015)

Complex quantitative traits, like size and behaviour, are a pervasive feature of natural populations. Quantitative trait variation is the product of both genetic and environmental factors, yet little ...

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Cell Cycle 14(3) , 354-63, (2015)

Cellular supply of deoxynucleoside triphosphates (dNTPs) is crucial for DNA replication and repair. In this study, we investigated the role of CMP/UMP kinase (CMPK), an enzyme catalyzes CDP formation,...

Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier.

Nat. Commun. 6 , 6716, (2015)

Brain metastasis is an important cause of mortality in breast cancer patients. A key event during brain metastasis is the migration of cancer cells through blood-brain barrier (BBB). However, the mole...