LEDAKRIN

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Names

[ CAS No. ]:
6514-85-8

[ Name ]:
LEDAKRIN

Chemical & Physical Properties

[ Density]:
1.269g/cm3

[ Boiling Point ]:
522ºC at 760 mmHg

[ Molecular Formula ]:
C₁₈H₂₁ClN₄O₂

[ Molecular Weight ]:
360.83800

[ Flash Point ]:
269.5ºC

[ Exact Mass ]:
360.13500

[ PSA ]:
73.98000

[ LogP ]:
5.05800

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR9244000

CHEMICAL NAME :: Acridine, 9-((3-(dimethylamino)propyl)amino)-1-nitro-, dihydrochloride

CAS REGISTRY NUMBER :: 6514-85-8

LAST UPDATED :: 199506

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C18-H20-N4-O2.2Cl-H

MOLECULAR WEIGHT :: 397.34

WISWESSER LINE NOTATION :: T C666 BNJ GNW IM3N1&1 &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25750 ug/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 725 ug/kg

TOXIC EFFECTS :: Gastrointestinal - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 34050 ug/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1010 ug/kg

TOXIC EFFECTS :: Gastrointestinal - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 1010 ug/kg

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting

MUTATION DATA

TYPE OF TEST :: Host-mediated assay

TEST SYSTEM :: Rodent - mouse Bacteria - Salmonella typhimurium

DOSE/DURATION :: 500 ug/kg

REFERENCE :: PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 31,661,1979

Related Compounds

Ledakrin
7-(2-methylphenyl)-4H,5H,6H,7H-[1,2,3,4]tetrazolo[1,5-a]pyrimidine
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
(S)-2-((tert-Butoxycarbonyl)amino)-4,4,4-trifluoro-3,3-dimethylbutanoic acid
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
Ethyl 4-(5-chlorothiophen-2-yl)-2-hydrazinylpyrimidine-5-carboxylate
1-(3,3-Difluorocyclopropen-1-yl)ethoxy-trimethylsilane
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide