Platinate(1-),[1,2,4-benzenetricarboxylato(3-)-kO1,kO2][(1R,2R)-1,2-cyclohexanediamine-kN,kN']-, hydrogen, (SP-4-3)- (9CI)

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Names

[ Name ]:
Platinate(1-),[1,2,4-benzenetricarboxylato(3-)-kO1,kO2][(1R,2R)-1,2-cyclohexanediamine-kN,kN']-, hydrogen, (SP-4-3)- (9CI)

[Synonym ]:
carboxyphthalato-1,2-diaminocyclohexaneplatinum

Chemical & Physical Properties

[ Boiling Point ]:
505.5ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₆N₂O₆Pt

[ Molecular Weight ]:
515.37500

[ Exact Mass ]:
515.06600

[ PSA ]:
113.96000

[ LogP ]:
1.68750

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TP1385500

CHEMICAL NAME :: Platinate (1-), (1,2,4-benzenetricarboxylato(3-)-O(sup 1),O(sup 2))(1,2-cyclohexanediamine- N,N')-, hydrogen, (SP-4-3)-

CAS REGISTRY NUMBER :: 65296-81-3

LAST UPDATED :: 199509

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C15-H18-N2-O6-Pt

MOLECULAR WEIGHT :: 517.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 84 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 46100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40130 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 70 mg/kg/5D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in bone marrow (not otherwise specified) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 33 umol/L

REFERENCE :: NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4- 1957- Volume(issue)/page/year: 34,379,1987

Related Compounds

4-{2-[5-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pyridin-2-yl]acetamido}but-2-ynoic acid
N-{5-azaspiro[3.4]octan-8-yl}-2-nitrobenzene-1-sulfonamide
3-(3-Bromo-5-methoxypyridin-4-yl)morpholine
5-Bromo-2,3-dimethyl-6-(1-methylcyclopropyl)imidazo[2,1-b][1,3]thiazole
5-Bromo-3-ethyl-6-(2-methylbutan-2-yl)imidazo[2,1-b][1,3]thiazole
5-Bromo-6-cycloheptyl-3-ethylimidazo[2,1-b][1,3]thiazole
9-bromo-2,3,4,5-tetrahydro-1H-2-benzazepine hydrochloride
benzyl N-(4,4-dimethyl-2-oxooxolan-3-yl)carbamate
3-Phenyl-2-[4-(trifluoromethyl)benzenesulfonyl]oxaziridine
tert-Butyl 4-(4-guanidinophenyl)piperidine-1-carboxylate

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