2,6-DIMETHYLHYDROQUINONE

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Names

[ CAS No. ]:
654-42-2

[ Name ]:
2,6-DIMETHYLHYDROQUINONE

[Synonym ]:
EINECS 211-505-2
1,4-Benzenediol, 2,6-dimethyl-
2,6-Dimethylbenzol-1,4-diol
2,6-dimethylbenzene-1,4-diol
2,6-DIMETHYLHYDROQUINONE
MFCD00016466
2,6-Dimethyl-1,4-benzenediol

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
284.6±35.0 °C at 760 mmHg

[ Melting Point ]:
154°C

[ Molecular Formula ]:
C8H10O2

[ Molecular Weight ]:
138.164

[ Flash Point ]:
141.1±20.5 °C

[ Exact Mass ]:
138.068085

[ PSA ]:
40.46000

[ LogP ]:
1.56

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.582

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MX5900000
CHEMICAL NAME :
Hydroquinone, 2,6-dimethyl-
CAS REGISTRY NUMBER :
654-42-2
BEILSTEIN REFERENCE NO. :
1862397
LAST UPDATED :
199701
DATA ITEMS CITED :
14
MOLECULAR FORMULA :
C8-H10-O2
MOLECULAR WEIGHT :
138.18
WISWESSER LINE NOTATION :
QR DQ B1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
186 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 2,23,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
117 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Behavioral - tremor
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 2,23,1964
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 2,23,1964 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
84 mg/kg
SEX/DURATION :
female 30 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948- Volume(issue)/page/year: 28,83,1956
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
7143 ug/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
REFERENCE :
JMIABM Journal of Medicine and International Medical Abstracts and Reviews. (Calcutta, India) V.19-31, 1956-66(?). Volume(issue)/page/year: 22,19,1958
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
100 mg/kg
SEX/DURATION :
female 4 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)
REFERENCE :
ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948- Volume(issue)/page/year: 28,18,1956
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
950 mg/kg
SEX/DURATION :
female 19 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 57,466,1955
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
3 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 57,466,1955
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
950 mg/kg
SEX/DURATION :
female 19 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 57,466,1955
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
200 mg/kg
SEX/DURATION :
female 4 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)
REFERENCE :
ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948- Volume(issue)/page/year: 28,18,1956
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
50 mg/kg
SEX/DURATION :
female 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
CMJRAY Calcutta Medical Journal. (Calcutta Medical Club, CMC House, 91-B Chittaranjan Ave., Calcutta 73, India) V.1- 1906- Volume(issue)/page/year: 49,354,1952
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
40 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - abortion Reproductive - Effects on Embryo or Fetus - other effects to embryo Reproductive - Effects on Newborn - stillbirth
REFERENCE :
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939- Volume(issue)/page/year: 14,228,1956 *** REVIEWS *** TOXICOLOGY REVIEW BCSTA4 Bulletin of the Calcutta School of Tropical Medicine. (Calcutta School of Tropical Medicine, Chittaranjan Ave., Calcutta 12, India) V.1- 1953- Volume(issue)/page/year: 10,85,1962

Safety Information

[ Hazard Codes ]:
Xi,T

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37/39

[ RIDADR ]:
UN 2811 6.1/PG 3

[ RTECS ]:
MX5900000

[ HS Code ]:
2907299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2,6-dimethyl-p-benzoquinone
  • 2,6-Xylenol
  • 3,5-Dimethyl-4-hydroxybenzaldehyde
  • Methanol
  • Hydroquinone
  • 1,3-dimethyl-2,5-bis-prop-2-ynyloxy-benzene
  • 2,6-dimethylcyclohex-3-ene-1,2-diol
  • 4-(cyclopenten-1-yl)-2,6-dimethylphenol
  • 4-(cyclopenten-2-yl)-2,6-dimethylphenol
  • Phenol,4-methoxy-2,6-dimethyl-

DownStream

  • 2,6-dimethyl-p-benzoquinone
  • 2-(benzenesulfonyl)-3,5-dimethylbenzene-1,4-diol
  • 4-(3,5-dimethyl-4-oxocyclohexa-2,5-dien-1-ylidene)-2,6-dimethylcyclohexa-2,5-dien-1-one
  • 1-(bromomethyl)-2,5-dimethoxy-3-methylbenzene
  • 1,4-Benzenediol,2,6-dimethyl-, 1,4-dibenzoate
  • 1,4-Benzenediol,2,6-dimethyl-, 4-benzoate
  • 1,3-bis(chloromethyl)-2,5-dimethoxy-4,6-dimethylbenzene
  • Benzaldehyde,3,6-dihydroxy-2,4-dimethyl-
  • Phenol,4-methoxy-2,6-dimethyl-
  • Methyl 4-hydroxy-2,6-dimethylbenzoate

Customs

[ HS Code ]: 2907299090

[ Summary ]:
2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

Related Compounds

  • 2,6-Dimethylhydroquinone
  • 2,6-dimethylhydroquinone
  • 3,5-dichloromethyl-2,6-dimethylhydroquinone dimethyl ether
  • 2-bromo-5,6-dimethylhydroquinone
  • 2,6-difluoro-N-[[4-[(E)-2-phenylethenyl]phenyl]carbamoyl]benzamide
  • 2,6-difluoro-N-[(4-octylphenyl)carbamoyl]benzamide
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 3-(2-Methoxyethyl)-1,4-diazepan-2-one
  • N-[(1-ethylcyclobutyl)methyl]hydroxylamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 8,8-Dimethyl-5-(2-methylpropyl)-1-oxa-4-azaspiro[5.5]undecane
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde