Leaf salicylate

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Names

[ Name ]:
Leaf salicylate

[Synonym ]:
(Z)-3-Hexenyl salicylate
Leaf salicylate
Benzoic acid, 2-hydroxy-, (3Z)-3-hexen-1-yl ester
Benzoic acid, 2-hydroxy-, (3Z)-3-hexenyl ester
cis-3-Hexenyl salicylate
MFCD00036486
EINECS 265-745-8
(3Z)-3-Hexen-1-yl salicylate
(3Z)-hex-3-en-1-yl 2-hydroxybenzoate
cis-3-Hexenylsalicylate

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
314.8±25.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₆O₃

[ Molecular Weight ]:
220.264

[ Flash Point ]:
126.2±15.9 °C

[ Exact Mass ]:
220.109940

[ PSA ]:
46.53000

[ LogP ]:
4.57

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.538

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VO3500000

CHEMICAL NAME :: Salicylic acid, 3-hexen-1-yl ester

CAS REGISTRY NUMBER :: 65405-77-8

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C13-H16-O3

MOLECULAR WEIGHT :: 220.29

WISWESSER LINE NOTATION :: QR BVO3U3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,373,1979 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,373,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,373,1979

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
VO3500000

[ HS Code ]:
2918230000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918230000

[ Summary ]:
2918230000 other esters of salicylic acid and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Sensitization to cis-3-hexenyl salicylate.

Contact Dermatitis 9(2) , 154, (1983)

Fragrance material review on cis-3-hexenyl salicylate.

Food Chem. Toxicol. 45 Suppl 1 , S402-5, (2007)

A toxicologic and dermatologic review of cis-3-hexenyl salicylate when used as a fragrance ingredient is presented.

Allergic contact dermatitis from octisalate and cis-3-hexenyl salicylate.

Dermatitis 17(3) , 152-5, (2006)

A 62-year-old woman developed allergic contact dermatitis from sunscreens containing octisalate (octyl salicylate, 2-ethylhexyl salicylate) and from a fragrance containing cis-3-hexenyl salicylate. Re...