Thozalinone

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Names

[ CAS No. ]:
655-05-0

[ Name ]:
Thozalinone

[Synonym ]:
2-Dimethylamino-5-phenyl-4-oxazolinon-(4)
Tozalinona [INN-Spanish]
2-Oxazolin-4-one,2-(dimethylamino)-5-phenyl
5-Phenyl-2-dimethylamino-2-oxazolin-4-on
2-(Dimethylamino)-5-phenyl-2-oxazolin-4-one
2-Dimethylamino-5-phenyl-4-oxo-2-oxazolin
2-Dimethylamino-4-oxo-5-phenyl-oxazolin
Tozalinonum [INN-Latin]
Stimsen
2-dimethylamino-5-phenyl-oxazol-4-one
Tozalinone
THOZALINONE

Chemical & Physical Properties

[ Density]:
1.19g/cm3

[ Boiling Point ]:
294.8ºC at 760 mmHg

[ Melting Point ]:
134.5ºC

[ Molecular Formula ]:
C₁₁H₁₂N₂O₂

[ Molecular Weight ]:
204.23

[ Flash Point ]:
132.1ºC

[ Exact Mass ]:
204.09000

[ PSA ]:
41.90000

[ LogP ]:
0.63770

[ Index of Refraction ]:
1.584

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RQ5775000

CHEMICAL NAME :: 2-Oxazolin-4-one, 2-(dimethylamino)-5-phenyl-

CAS REGISTRY NUMBER :: 655-05-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C11-H12-N2-O2

MOLECULAR WEIGHT :: 204.25

WISWESSER LINE NOTATION :: T5NV DO CHJ CR& EN1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >3000 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Behavioral - somnolence (general depressed activity)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1240 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 570 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

3-fluoro-N-[(pyridin-2-yl)methyl]-5-(trifluoromethyl)pyridin-2-amine
3-fluoro-N-[(pyridin-4-yl)methyl]-5-(trifluoromethyl)pyridin-2-amine
6-(4-{[(2-Cyclopropyl-5,6-dimethylpyrimidin-4-yl)oxy]methyl}piperidin-1-yl)-3-methyl-3,4-dihydropyrimidin-4-one
6-(4-Methoxypiperidin-1-yl)spiro[4.5]decan-8-ol
2-[4-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)piperidin-1-yl]-5H,6H,7H-cyclopenta[b]pyridine-3-carbonitrile
N,N-dimethyl-6-(4-{[(3-methylpyridin-4-yl)oxy]methyl}piperidin-1-yl)pyrimidin-4-amine
3,5-Dichloro-2-[4-(1,3-thiazol-2-yloxy)piperidin-1-yl]pyridine
N-(3-methyloxetan-3-yl)propan-2-imine
2,6-Dioxa-8-azaspiro[3.5]nonane-7-carboxylic acid
N-[1-(3-bromopyridin-2-yl)piperidin-4-yl]-5-chloro-N-methylpyrimidin-2-amine

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