HA14-1

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Names

[ CAS No. ]:
65673-63-4

[ Name ]:
HA14-1

[Synonym ]:
Ethyl (4R)-2-amino-6-bromo-4-[(1R)-1-cyano-2-ethoxy-2-oxoethyl]-4H-chromene-3-carboxylate
Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
S1071_Selleck
4H-1-Benzopyran-4-acetic acid, 2-amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-, ethyl ester
HA 14-1
4H-1-Benzopyran-4-acetic acid, 2-amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-, ethyl ester, (αR,4R)-
HA14-1

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
535.1±50.0 °C at 760 mmHg

[ Melting Point ]:
105ºC

[ Molecular Formula ]:
C17H17BrN2O5

[ Molecular Weight ]:
409.231

[ Flash Point ]:
277.4±30.1 °C

[ Exact Mass ]:
408.032074

[ PSA ]:
111.64000

[ LogP ]:
3.70

[ Appearance of Characters ]:
powder

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.574

[ Storage condition ]:
−20°C

[ Water Solubility ]:
DMSO: 26 mg/mL

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2932209090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ethyl cyanoacetate
  • 5-Bromosalicylaldehyde

DownStream

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Morpholino artifacts provide pitfalls and reveal a novel role for pro-apoptotic genes in hindbrain boundary development.

Dev. Biol. 350 , 279-89, (2011)

Morpholino antisense oligonucleotides (MOs) are widely used as a tool to achieve loss of gene function, but many have off-target effects mediated by activation of Tp53 and associated apoptosis. Here, ...

The pro-survival role of autophagy depends on Bcl-2 under nutrition stress conditions.

PLoS ONE 8 , e63232, (2013)

Autophagy can be induced under nutrition stress conditions. Bcl-2 is a pro-survival protein which inhibits apoptosis and autophagy. However, the role of Bcl-2 in autophagy regulation and cell survival...


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Related Compounds

  • HA14-1
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  • Solvent Yellow 14
  • TC-SP 14
  • Acid Mordant Orange 14
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  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
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  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
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  • N-[3-(Aminooxy)propyl]-N-butyl-1-butanamine