Reversine

Suppliers

Names

[ Name ]:
Reversine

[Synonym ]:
N-cyclohexyl-N-[4-(morpholin-4-yl)phenyl]-1H-purine-2,6-diamine
2vgo
1H-purine-2,6-diamine, N-cyclohexyl-N-[4-(4-morpholinyl)phenyl]-
2-(4-morpholinoanilino)-6-cyclohexylaminopurine
6-N-cyclohexyl-2-N-(4-morpholin-4-ylphenyl)-7H-purine-2,6-diamine
Reversine
9H-Purine-2,6-diamine, N-cyclohexyl-N-[4-(4-morpholinyl)phenyl]-
N-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-3H-purine-2,6-diamine

Chemical & Physical Properties

[ Density]:
1.343±0.06 g/cm3

[ Boiling Point ]:
736.4±70.0 °C at 760 mmHg

[ Melting Point ]:
305 ºC (decomp)

[ Molecular Formula ]:
C₂₁H₂₇N₇O

[ Molecular Weight ]:
393.485

[ Flash Point ]:
399.2±35.7 °C

[ Exact Mass ]:
393.227722

[ PSA ]:
90.99000

[ LogP ]:
1.23

[ Appearance of Characters ]:
solid

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.712

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
Insuluble (3.7E-4 g/L) (25 ºC)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Nek2A destruction marks APC/C activation at the prophase-to-prometaphase transition by spindle-checkpoint-restricted Cdc20.

J. Cell Sci. 128(8) , 1639-53, (2015)

Nek2 isoform A (Nek2A) is a presumed substrate of the anaphase-promoting complex/cyclosome containing Cdc20 (APC/C(Cdc20)). Nek2A, like cyclin A, is degraded in mitosis while the spindle checkpoint is...

Feedback regulation between atypical E2Fs and APC/CCdh1 coordinates cell cycle progression.

EMBO Rep. 17 , 414-27, (2016)

E2F transcription factors control the oscillating expression pattern of multiple target genes during the cell cycle. Activator E2Fs, E2F1-3, induce an upswing of E2F targets, which is essential for th...

Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function.

Nat. Commun. 6 , 8399, (2015)

Warsaw breakage syndrome (WABS) is caused by defective DDX11, a DNA helicase that is essential for chromatid cohesion. Here, a paired genome-wide siRNA screen in patient-derived cell lines reveals tha...

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