Apramycin sulfate

Suppliers

Names

[ Name ]:
Apramycin sulfate

[Synonym ]:
Apramycin sulphate
Apramycin sulfate
(2R,3R,4S,5S,6S)-5-Amino-2-{[(2R,3S,4R,4aR,6S,7R,8aS)-7-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy}-4-hydroxy-3-(methylamino)octahydropyrano[3,2-b]pyran-2-yl]oxy}-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol sulfate (1:1) (non-preferred name)
UNII-8UYL6NAZ3Q
(2R,3S,4R,4aR,6S,7R,8aS)-7-Amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy}-4-hydroxy-3-(methylamino)octahydropyrano[3,2-b]pyran-2-yl 4-amino-4-deoxy-α-D-glucopyranoside sulfate (1:1)
Apramycin (sulfate)

Chemical & Physical Properties

[ Density]:
1.56

[ Boiling Point ]:
949.8ºC at 760 mmHg

[ Melting Point ]:
>168ºC (dec.)

[ Molecular Formula ]:
C₂₁H₄₃N₅O₁₅S

[ Molecular Weight ]:
637.656

[ Flash Point ]:
528.2ºC

[ Exact Mass ]:
637.247620

[ PSA ]:
41.99000

[ LogP ]:
3.82570

[ Appearance of Characters ]:
white to light yellow

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: soluble25mg/mL | Soluble in water.

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H360

[ Precautionary Statements ]:
P201-P308 + P313

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P2 (EN 143) respirator cartridges;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R61;R35

[ Safety Phrases ]:
S53-S26-S36/37/39-S45

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29419000

Customs

[ HS Code ]: 29419000

Articles

Genomic analysis reveals distinct concentration-dependent evolutionary trajectories for antibiotic resistance in Escherichia coli.

DNA Res. 21(6) , 711-26, (2014)

Evolution of bacteria under sublethal concentrations of antibiotics represents a trade-off between growth and resistance to the antibiotic. To understand this trade-off, we performed in vitro evolutio...

Field trial evaluating changes in prevalence and patterns of antimicrobial resistance among Escherichia coli and Enterococcus spp. isolated from growing broilers medicated with enrofloxacin, apramycin and amoxicillin

Vet. Microbiol. 139(3-4) , 284-92, (2009)

The present study investigates, under field conditions, the influence of antimicrobial administration on prevalence and patterns of antimicrobial resistance among Escherichia coli and Enterococcus spp...

Enhancement of bacterial competitive fitness by apramycin resistance plasmids from non-pathogenic Escherichia coli.

Biol. Lett. 2(3) , 463-5, (2006)

The study of antibiotic resistance has in the past focused on organisms that are pathogenic to humans or animals. However, the development of resistance in commensal organisms is of concern because of...

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