Distamycin A hydrochloride

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Names

[ CAS No. ]:
6576-51-8

[ Name ]:
Distamycin A hydrochloride

[Synonym ]:
herperal
EINECS 229-505-6
estalimicinaclorhidrato
STALLIMYCIN HCL
fi6426
N''-(2-Amidinoethyl)-4-formamido-1,1',1''-trimethyl-N,4':N',4''-ter(pyrrole-2-carboxamide) monohydrochloride
distamycin A monohydrochloride
N-[5-({5-[(3-Amino-3-iminopropyl)carbamoyl]-1-methyl-1H-pyrrol-3-yl}carbamoyl)-1-methyl-1H-pyrrol-3-yl]-4-formamido-1-methyl-1H-pyrrole-2-carboxamide hydrochloride (1:1)
DISTAMYCIN A HCL
1H-Pyrrole-2-carboxamide, N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-4-[[[4-(formylamino)-1-methyl-1H-pyrrol-2-yl]carbonyl]amino]-1-methyl-, hydrochloride (1:1)
Distamycin A hydrochloride from Streptomyces distallicus
stallimycinhydrochloride
1H-Pyrrole-2-carboxamide, N-(5-(((3-amino-3-iminopropyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-4-(((4-(formylamino)-1-methyl-1H-pyrrol-2-yl)carbonyl)amino)-1-methyl-, monohydrochloride
stallimycin monohydrochloride
N-(5-(((3-Amino-3-iminopropyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-4-(((4-(formylamino)-1-methyl-1H-pyrrol-2-yl)carbonyl)amino)-1-methyl-1H-pyrrole-2-carboxamide monohydrochloride
distamycin A hydrochloride from*streptomyces dist
STALLIMYCIN HYDROCHLORIDE

Chemical & Physical Properties

[ Boiling Point ]:
715.4ºC at 760 mmHg

[ Molecular Formula ]:
C22H28ClN9O4

[ Molecular Weight ]:
517.969

[ Flash Point ]:
386.4ºC

[ Exact Mass ]:
517.195251

[ PSA ]:
181.06000

[ LogP ]:
3.67870

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WZ7110000
CAS REGISTRY NUMBER :
6576-51-8
LAST UPDATED :
199409
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C22-H27-N9-O4.Cl-H
MOLECULAR WEIGHT :
518.04
WISWESSER LINE NOTATION :
T5NJ A1 BVM2YZUM DMV- BT5NJ A1 EMV- BT5NJ A1 DMVH &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
169 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA adduct
TEST SYSTEM :
Mammal - species unspecified Lymphocyte
DOSE/DURATION :
200 umol
REFERENCE :
EJBCAI European Journal of Biochemistry. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1967- Volume(issue)/page/year: 26,81,1972

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R43

[ Safety Phrases ]:
S36/S37

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-METHYL-4-NITRO-1H-PYRROLE-2-CARBOXYLIC ACID
  • 4-amino-1-methyl-1H-pyrrole-2-carboxylicacid
  • 1-Methyl-4-nitro-1H-pyrrole-2-carboxylic acid ethyl ester
  • 4-tert-butoxycarbonylamino-1-methyl-1h-pyrrole-2-carboxylic acid
  • 1-Methyl-1H-pyrrole-2-carboxylic acid
  • 1-METHYL-4-NITRO-1H-PYRROLE-2-CARBONYL CHLORIDE
  • Methyl 1-methyl-4-nitro-1H-pyrrole-2-carboxylate
  • Benzyl 4-Amino-1-methylpyrrole-2-carboxylate
  • benzyl 4-[[(tert-butyloxy)carbonyl]amino]-1-methyl-pyrrole-2-carboxylate
  • cesium 4-((tert-butoxycarbonyl)amino)-1-methyl-1H-pyrrole-2-carboxylate

DownStream

  • N-[5-[[5-(2-cyanoethylcarbamoyl)-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-formamido-1-methylpyrrole-2-carboxamide
  • N-[5-[[5-[[3-(dimethylamino)-3-iminopropyl]carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-formamido-1-methylpyrrole-2-carboxamide

Related Compounds

  • (7S,9R,10R)-7,10-bis[[(2S,4S,5S,6S)-4-(dimethylamino)-5-hydroxy-6-methyloxan-2-yl]oxy]-9-ethyl-4,6,9,11-tetrahydroxy-8,10-dihydro-7H-tetracene-5,12-dione,dihydrochloride
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  • 1-(4-Fluoro-2-hydroxy-6-methoxyphenyl)ethan-1-one
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide