1b-D-Arabinofuranosyl-5-azacytosine

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Names

[ CAS No. ]:
65886-71-7

[ Name ]:
1b-D-Arabinofuranosyl-5-azacytosine

[Synonym ]:
4-Amino-1-(β-D-arabinofuranosyl)-1,3,5-triazin-2(1H)-one
1b-D-Arabinofuranosyl-5-azacytosine
4-Amino-1b-D-arabinofuranosyl-s-triazin-2(1H)-one
Fazarabine
5-azacytosine arabinoside
ara-AC
1-β-D-Arabinofuranosyl-5-azacytosine
4-Amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
1,3,5-Triazin-2(1H)-one, 4-amino-1-β-D-arabinofuranosyl-
5-azaaracytidine

Chemical & Physical Properties

[ Density]:
2.1±0.1 g/cm3

[ Boiling Point ]:
534.5±60.0 °C at 760 mmHg

[ Melting Point ]:
228-230ºC (decomposes)

[ Molecular Formula ]:
C8H12N4O5

[ Molecular Weight ]:
244.205

[ Flash Point ]:
277.0±32.9 °C

[ Exact Mass ]:
244.080765

[ PSA ]:
143.72000

[ LogP ]:
-1.99

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.823

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XZ2854400
CHEMICAL NAME :
s-Triazin-2(1H)-one, 4-amino-1-beta-D-arabinofuranosyl-
CAS REGISTRY NUMBER :
65886-71-7
LAST UPDATED :
199206
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C8-H12-N4-O5
MOLECULAR WEIGHT :
244.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human
DOSE/DURATION :
1557 ug/kg/72H-C
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting Blood - agranulocytosis

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - mouse Leukocyte
DOSE/DURATION :
2 umol/L
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 24,297,1983

Related Compounds

  • 5,6-dihydro-1-β-D-arabinofuranosyl-5-azacytosine
  • 5-Hydroxymethyl-arauridine
  • 1-(5-Phospho-beta-D-arabinofuranosyl)-5-fluorouracil
  • 2-Amino-1-β-D-arabinofuranosyl-5-methyl-4(1H)-pyrimidinone
  • 2,2-Anhydro-1-beta-D-arabinofuranosyl-5-fluorocytosine
  • 2,2'-anhydro-1-(β-D-arabinofuranosyl)-5-(methoxycarbonylmethyl)-uracil
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • [5-(Trifluoromethyl)pyridin-2-YL]methanesulfonyl chloride
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide