Colchinol, N-acetyl-, methyl ether

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Names

[ CAS No. ]:
65967-01-3

[ Name ]:
Colchinol, N-acetyl-, methyl ether

[Synonym ]:
(-)-N-acetylcochinol methyl ether
(S)-N-acetyl-O-methyl-colchinol
(S)-N-acetyl-O-methyl-colchicinol
Acetamide,N-(6,7-dihydro-3,9,10,11-tetramethoxy-5H-dibenzo(a,c)cyclohepten-5-yl)-,(S)
N-Azetyl-colchinol-methylaether [German]
Colchinol,N-acetyl-,methyl ether
N-acetylallocolchinol O-methyl ether
N-Acetylcolchinol methyl ether
N-Acetylcolchinol O-methyl ether
N-acetylcolchcinol methyl ester

Chemical & Physical Properties

[ Density]:
1.21g/cm3

[ Boiling Point ]:
599ºC at 760 mmHg

[ Molecular Formula ]:
C21H25NO5

[ Molecular Weight ]:
371.42700

[ Flash Point ]:
316.1ºC

[ Exact Mass ]:
371.17300

[ PSA ]:
66.02000

[ LogP ]:
3.90230

[ Index of Refraction ]:
1.581

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GH1008000
CHEMICAL NAME :
Colchinol, N-acetyl-, methyl ether
CAS REGISTRY NUMBER :
65967-01-3
LAST UPDATED :
199409
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C21-H25-N-O5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
5 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC. Volume(issue)/page/year: 85,235,1920
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
320 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC. Volume(issue)/page/year: 85,235,1920

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • N-deacetylcolchinyl methyl ether
  • Ethanoic anhydride
  • Colchicine
  • (5R)-6,7-dihydro-3,9,10,11-tetramethoxy-5H-dibenzo[a,c]cyclohepten-5-ol
  • hexacarbonyl[μ-η4-(1,2,3,9-tetramethoxy-5H-dibenzo[a,c]cycloheptyne)]dicobalt
  • 6,7-dihydro-3,9,10,11-tetramethoxy-5H-dibenzo[a,c]cyclohepten-5-one
  • diazomethane
  • N-ACETYL COLCHINOL

DownStream

Related Compounds

  • N-ACETYL COLCHINOL
  • N-acetylcolchinol methyl ether
  • D-Serine, N-acetyl-, methyl ester (9CI)
  • methyl (1Z)-N-[acetyl(methyl)carbamoyl]oxyethanimidothioate
  • 2-cyanoethyl (1E)-N-[acetyl(methyl)carbamoyl]oxyethanimidothioate
  • 2-methoxy-naphthaldehyde-(1)-α oxime N-methyl ether
  • Benzonitrile, 4-[amino(5-chloro-2-benzofuranyl)methyl]-
  • 2-Methyl-1-(3-methyl-1-benzofuran-2-yl)propan-1-amine
  • N-(6-((4-oxo-4-((1-phenylethyl)amino)butyl)thio)pyridazin-3-yl)cyclopropanecarboxamide
  • N-(6-((4-oxo-4-(((tetrahydrofuran-2-yl)methyl)amino)butyl)thio)pyridazin-3-yl)thiophene-2-carboxamide
  • 1-(4-([1,2,4]Triazolo[4,3-b]pyridazin-6-yl)piperazin-1-yl)-2-(benzo[d][1,3]dioxol-5-yloxy)propan-1-one
  • 5-(Phenylsulfamoyl)furan-2-carboxylic acid
  • 5-((2-Carbamoylpyrrolidin-1-yl)sulfonyl)furan-2-carboxylic acid
  • N1-(benzo[d][1,3]dioxol-5-yl)-N2-(2-(1-methyl-1H-pyrrol-2-yl)-2-morpholinoethyl)oxalamide
  • N1-(benzo[d][1,3]dioxol-5-ylmethyl)-N2-(2-(1-methyl-1H-pyrrol-2-yl)-2-morpholinoethyl)oxalamide
  • N1-(2,4-dimethoxyphenyl)-N2-(2-(1-methyl-1H-pyrrol-2-yl)-2-morpholinoethyl)oxalamide
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