AMG-517

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Names

[ CAS No. ]:
659730-32-2

[ Name ]:
AMG-517

[Synonym ]:
BD-0082
N-(4-(6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yloxy)benzo[d]thiazol-2-yl)acetamide
UNII-172V4FBZ75
N-[4-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)-1,3-benzothiazol-2-yl]acetamide
Acetamide, N-[4-[[6-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2-benzothiazolyl]-
N-[4-({6-[4-(Trifluoromethyl)phenyl]-4-pyrimidinyl}oxy)-1,3-benzothiazol-2-yl]acetamide
N-[4-[[6-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2-benzothiazolyl]-acetamide
AMG-517
N-(4-(6-(4-trifluoromethylphenyl)pyrimidin-4-yloxy)benzothiazol-2-yl)acetamide
N-(4-[6-(4-trifluoromethyl-phenyl)-pyrimidin-4-yloxy]-benzothiazol-2-yl)-acetamide
AMG517
AMG 517

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Melting Point ]:
227ºC

[ Molecular Formula ]:
C20H13F3N4O2S

[ Molecular Weight ]:
430.403

[ Exact Mass ]:
430.071136

[ PSA ]:
108.73000

[ LogP ]:
5.41

[ Index of Refraction ]:
1.645

[ Storage condition ]:
-20℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-[6-(4-trifluoromethylphenyl)pyrimidin-4-yloxy]benzothiazol-2-ylamine
  • Ethanoic anhydride
  • 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine
  • 2-amino-1,3-benzothiazol-4-ol

DownStream

Related Compounds

  • N-[4-[6-[4-[1-(4-fluorophenyl)ethyl]piperazin-1-yl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
  • AMG 837 hemicalcium salt
  • AMG-416
  • AMG 837 (calcium hydrate)
  • AMG 8718
  • AMG-510(Sotorasib)
  • 4-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanamido]-3-methylbenzoic acid
  • 2-[N-(cyclopropylmethyl)-1-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclohexyl]formamido]acetic acid
  • 5-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclopentaneamido]pyridine-3-carboxylic acid
  • 2-cyclopropyl-2-{[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclohexyl]formamido}propanoic acid
  • 3-[(3,5-dibromopyrazin-2-yl)carbamoyl]-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
  • 4-(1,1-dioxo-1lambda6,4-thiazepan-4-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-oxobutanoic acid
  • 1-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylpropanoyl]-3,3-dimethylpiperidine-2-carboxylic acid
  • 1-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoyl]-3,3-dimethylpiperidine-2-carboxylic acid
  • 4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-({2-[(trifluoromethyl)sulfanyl]ethyl}carbamoyl)butanoic acid
  • 3-{2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclopentyl]acetamido}-2-methoxypropanoic acid
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